Internal Medicine Alert – April 30, 2021
April 30, 2021
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Is Metformin a Wonder Drug?
An analysis of patients taking metformin for diabetes showed they were less likely to report back, knee, neck/shoulder, or multisite musculoskeletal pain.
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Accounting for Patient Preference, Cardiovascular Disease Risk in Statin Therapy
Researchers weighed patient preferences and risks regarding statin therapy after reviewing 10-year atherosclerotic cardiovascular disease risk scores.
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Is Empagliflozin Safe in Combination with a Neprilysin Inhibitor for Heart Failure?
A prespecified subgroup analysis of heart failure patients with reduced ejection fraction who were on neprilysin inhibitors before empagliflozin was administered (vs. those not on neprilysin inhibitors) showed the reduction in mortality and hospital admissions for heart failure was not attenuated by concurrent neprilysin use.
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Antibiotics: Less Is Better, Sometimes
In England, and likely in many other areas of the world, antibiotics are given for longer than necessary. Excessively long durations of antibiotic use do not help patients and risk leading to more resistant infections.
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Herpes Zoster Vaccine: Effective but Underused
The adjuvanted recombinant herpes zoster vaccine is highly effective in practice, but it is vastly underused.
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Dasiglucagon Injection (Zegalogue)
Dasiglucagon should be prescribed to treat severe hypoglycemia in pediatric and adult patients (≥ age 6 years).