Internal Medicine Alert – November 30, 2004

November 30, 2004

• Sweatin’ with the Oldies

  Night sweats, day sweats, and hot flashes occur frequently in the elderly and are more closely associated with common ailments than serious illnesses.

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• Obesity — Is Surgery Finally Here for This Important CV Risk Factor?

  Effective weight loss was achieved in morbidly obese patients after undergoing bariatric surgery. A substantial majority of patients with diabetes, hyperlipidemia, hypertension, and obstructive sleep apnea experienced complete resolution or improvement.

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• A New Class of Drugs that Lowers HbA1C and Promotes Weight Loss in Type 2 Diabetes

  Exenatide (Extendin-4) significantly lowered HbA1C and caused weight loss in type 2 diabetes patients.

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• Resolution of Hepatitis C Infection

  Studies on HCV infection resolution show that PBMC HCV-RNA may remain, despite clearance of the virus from plasma.

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• Pharmacology Update: Histrelin Implant (Vantas)

  FDA has approved a long-acting implant for the palliative treatment of prostate cancer.

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• Clinical Briefs

  The consequences of sleep deprivation, as measured in otherwise healthy men, include elevations of sympathetic activity, increased levels of cortisol, and altered glucose metabolism.

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