Internal Medicine Alert – October 30, 2011
October 30, 2011
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Replacing Warfarin for Atrial Fibrillation Treatment — A Foregone Conclusion!
In nonvalvular atrial fibrillation patients, rivaroxaban was noninferior to warfarin for the prevention of stroke or systemic embolism. However, an intention-to-treat analysis did not show superiority of rivaroxaban over warfarin. -
Strokes More Severe When Occurring During Sleep
It has been well recognized that a peak in stroke onset occurs during the early morning hours. This possible circadian periodicity is not well understood, and may in part represent stroke onset earlier during the night that goes unrecognized until the patient arouses. -
A Better Understanding of Nocturia in Patients with Interstitial Cystitis
Both urgency and bladder pain can lead to nocturia in patients with interstitial cystitis. -
ACE Inhibitors/ARBs for Aortic Stenosis?
The authors conclude that this large observational study suggests ACEI or ARB therapy is associated with an improved survival and a lower risk of cardiovascular events in patients with aortic stenosis. -
Vemurafenib Tablets (Zelboraf)
A kinase inhibitor for late-stage melanoma and its companion diagnostic test have been approved by the FDA. -
Clinical Briefs By Louis Kuritzky, MD
For many patients with moderate- severe chronic obstructive pulmonary disease, acute exacerbations (AECOPD) are highly problematic.