Internal Medicine Alert – April 15, 2005
April 15, 2005
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High-Dose Vitamin E Increases All-Cause Mortality
A meta-analysis of 19 clinical trials found that vitamin E intake greater than the recommended 400 IU/day found a statistically significant relationship between increased dosage and all-cause mortality when compared to both controls and lower doses. -
Does Periodontal Inflammation Produce CAD?
This study provides evidence of a direct relationship between periodontal microbiology and subclinical atherosclerosis. This relationship exists independent of C-reactive protein. -
Idiopathic Edema and Obstructive Sleep Apnea in Women
In women, obstructive sleep apnea appears to be associated with idiopathic edema, even after controlling for obesity. -
The WHI Results on Urinary Incontinence
Conjugated equine estrogen alone and CEE + MPA increased the risk of urinary incontinence among continent women and worsened the characteristics of urinary incontinence among symptomatic women after 1 year. -
Pharmacology Update: Palifermin Injection (KepivanceTM)
Amgen has received approval to market palifermin. The drug is approved to decrease the incidence and duration of severe oral mucositis in patients with hematologic malignancies undergoing chemotherapy, with or without radiation, followed by a bone marrow transplant. -
Clinical Briefs
Although all strokes are potentially debilitating, intracerebral hemorrhage is often the most disabling. -
ECG Review: When to Pace Sick Sinus?
The non-continuous lead II rhythm strips shown in the Figure were obtained from an asymptomatic 76-year-old woman. Are these rhythms diagnostic (or at least consistent) with sick sinus syndrome? Is permanent pacemaker implantation indicated? On what does your answer depend? -
Pharmacology Watch: Preparing for the Possibility of a Bird Flu Pandemic
The possibility of a bird flu pandemic has health officials worldwide in a high state of alert. -
Clinical Briefs in Primary Care Supplement