Internal Medicine Alert – July 30, 2004

July 30, 2004

• Tired of Diets? Sleep and Lose Weight!

  Patients are desperately looking for weight loss plans that do not involve consuming fewer calories or burning more of them. Perhaps they should be told about the relationship between sleep, weight, and appetite.

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• Treat Erectile Dysfunction with Lifestyle Changes

  A randomized, controlled trial of obese men, ages 35 to 55, with erectile dysfunction showed that weight loss and increased physical activity allowed 31% to regain sexual function and most reduced their cardiac risk factors.

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• The Natural History of Prostate Cancer

  Among patients with early, localized prostate cancer, the mortality rate accelerated after 15 years.

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• COX-2 Inhibitor Controversy

  Current rofecoxib use was associated with a higher risk of acute myocardial infarction or admission for heart failure compared to celecoxib.

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• Pharmacology Update: Trospium Chloride Tablets (Sanctura^TM)

  A new quaternary ammonium compound has been approved for the treatment of overactive bladder.

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• Clinical Briefs

  Prevalence of Prostate Cancer Among Men with a Prostate-Specific Antigen Level < 4.0 ng/mL; Mirtazapine for Reducing Nocturnal Itch in Patients with Chronic Pruritus; A Factorial Trial of Six Interventions for the Prevention of Postoperative Nausea and Vomiting

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