Internal Medicine Alert – May 30, 2003

May 30, 2003

• What Are the Chances That a Mole Will Turn to the Dark Side?

  Although the phenomenon of cutaneous melanoma (CM) arising from melanocytic nevi (MN) is known, the transformation rate of MN into CM is not. Tsao and associates set out to calculate the rate, using published data and making some assumptions to ease the calculation.

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• The Urine Color Test with Isoniazid Treatment of Latent Tuberculosis Infection

  Noncompliance with treatment for latent tuberculosis can be monitored with the aid of a special urine test that checks for metabolites of isoniazid.

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• Silent Strokes Predispose to Dementia

  This study concludes that there may be a direct association between ischemia and the development of Alzheimers pathology (plaques and neurofibrillary tangles), or alternatively, ischemia may unmask otherwise mild cases of AD.

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• Obesity: Death, Dollars, and the Prospects for Treatment

  The management of the obesity epidemic is complex, but there are some interventions that can be helpful.

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• Pharmacology Update: Aprepitant Capsules (Emend — Merck & Co)

  The FDA has approved aprepitant for preventing both acute and delayed nausea and vomiting associated with chemotherapy.

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• Clinical Briefs

  Influenza Vaccination and Reduction in Hospitalizations; Screening Men for Prostate and Colorectal Cancer; Weight Loss in CHF and Treatment with ACE-I

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