Infectious Disease Alert – June 1, 2015
June 1, 2015
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Hospital Wards with Higher Rates of Antibiotic Prescribing Are Associated with Increased Risk for C. difficile Infection
A retrospective observational study found that among hospitalized patients, ward-level antibiotic prescribing was associated with a significantly increased risk for C. difficile infection beyond what would be expected with patient-level antibiotic use.
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Early, Goal-directed Therapy of Septic Shock
ABSTRACT & COMMENTARY: Hemodynamic management did not lead to an improvement in outcome.
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Early Benefits of HPV Vaccination
A large study of HPV vaccination among girls 13-14 years of age demonstrated significant reduction of cervical dysplasia that was detectable by 17 years of age, providing justification for not delaying HPV vaccination in girls until older adolescence.
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Lung Ultrasound to Diagnose Pneumonia in Children
Whether based on history, tachypnea, or X-ray findings, the diagnosis of pneumonia in children is incompletely accurate. Ultrasound is a reasonable alternative tool for the diagnosis of childhood pneumonia.
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Initial Antiretroviral Regimens — New Recommendations
Four of the five recommended initial antiretroviral regimens in treatment-naïve adolescents and adults are based on integrase strand transfer inhibitors.
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Nasal Screening for MRSA: The New Basis for De-escalation of Empiric Antibiotics?
The high negative predictive value of a negative nasal screen for methicillin-resistant Staphylococcus aureus suggests these patients do not have lower respiratory tract infections caused by the organism.
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Treatment of Invasive Aspergillosis: Are Two Drugs Better Than One?
Although potential benefit may have been detected in a post hoc subset analysis, the addition of anidulafungin in the initial phase of primary treatment of suspected or documented invasive aspergillosis was not associated with a significant improvement in survival.
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Infectious Disease Alert Updates
Surprise! My Kid Has Chlamydia; More on C. diff. Transmission; Staph. aureus Carriage and Moustaches