Infectious Disease Alert – June 1, 2010
June 1, 2010
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Microbial Translocation and HIV Infection
Twenty-one patients with HIV-1/AIDS, seven patients with hiv-2/aids, 43 patients with HIV-1 chronic infection, and 66 patients with HIV-2 chronic infection in Guinea-Bissau were studied along with 66 HIV-negative policemen. -
Pharmacokinetic, Pharmacodynamic, and Clinical Efficacy of Continuous or Extended Infusion Regimens of Piperacillin/Tazobactam
Piperacillin/Tazobactam (P/T) offers one of the broadest antimicrobial spectrums, and is equipped with an effective mechanism to maintain its potency in the presence of beta-lactamases. -
Tetracycline and T-cell Activation
CD4+ t cells were obtained from HIV-negative donors and HIV-positive patients receiving HAART with suppressed viremia. Using a single-cycle replication system and an X4 pseudovirus used to infect cells, minocycline, at concentrations from 0-50 ug/mL, demonstrated a dose-dependent reduction in the percentage of infected cells. -
Updates by Carol A. Kemper, MD, FACP
These authors assessed the benefits of antiviral therapy of the index flu patient on reduced viral shedding and prevention of secondary household cases who did not receive chemoprophylaxis. -
Pharmacology Watch: Atypical Fractures and Bisphosphonate Therapy
In this issue: Fractures and bisphosphonate therapy, warfarin anticoagulation and influenza vaccine and cotrimoxazole, antiplatelet therapy with clopidogrel and aspirin, FDA Actions. -
Clinical Briefs in Primary Care supplement