Hospital Medicine Alert – May 1, 2017

May 1, 2017

• The ABCs of In-hospital Cardiac Arrest

  SYNOPSIS: In this large, propensity-matched cohort study of patients who experienced an in-hospital cardiac arrest, patients who underwent endotracheal intubation had worse survival to hospital discharge than patients who were not intubated.

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• Surviving Sepsis Campaign Guidelines Bundle: Studying How Improved Compliance Might Affect Outcomes

  SYNOPSIS: Improved compliance with the Surviving Sepsis Campaign guidelines bundle was associated with a non-statistically significant decrease in the in-hospital mortality of severe sepsis patients.

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• Clindamycin Improves Outcomes in Necrotizing Fasciitis due to Group A Streptococcus

  SYNOPSIS: Using a murine model of necrotizing fasciitis, investigators determined that clindamycin inhibits key virulence factors of Group A Streptococcus, and should be given as soon as possible and at high doses to reach levels above MIC in affected tissues.

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• Study Challenges Orthodoxy of IV Hydration for Prevention of Contrast Nephropathy

  SYNOPSIS: This trial randomized 660 patients with chronic kidney disease and a planned procedure requiring intravascular iodinated contrast to prophylactic hydration or to no hydration. No hydration was found to be non-inferior for prevention of contrast-induced nephropathy and saved significant costs.

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