Hospital Medicine Alert – February 1, 2011
February 1, 2011
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Omeprazole and Clopidogrel — Is There a Clinically Meaningful Interaction?
Gastrointestinal (GI) bleeding is a major complication of dual anti-platelet therapy (DAPT) with aspirin and clopidogrel. -
Study Supports More Appropriate Blood Pressure Levels for Post-ACS Patients
The relationship between blood pressure and cardiovascular events remains controversial, especially in patients with coronary artery disease who may need increased pressures to have adequate myocardial perfusion. -
Early Aggressive Therapy to Reduce Serum Lactate Levels Improves Outcomes in Critically Ill Patients
In a multicenter study, critically ill patients with initial hyperlactatemia had improved outcomes (including shorter ICU stays and lower adjusted mortality) compared to control patients when they were managed for the first 8 hours with a resuscitation protocol targeted at reducing the lactate level by at least 20% every 2 hours. -
Managing Influenza in Patients with Hematologic Malignancies
A 74-year retired veterinarian presents to the emergency department (ED) with shortness of breath. He was recently diagnosed with diffuse large-cell lymphoma with prominent abdominal lymphadenopathy and positive bone marrow and has been treated with two cycles of R-CHOP. -
Cognition after Sepsis
Episodes of severe sepsis in older adults is associated with worsening cognition and functional status.Source: Iwashyna TJ, et al. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 2010;304:1787-94.