Internal Medicine Alert – November 30, 2022

November 30, 2022

• Spironolactone May Help Treat Chronic Alcoholism

  Both animal and human studies suggest spironolactone might be a new agent for helping patients with alcohol use disorder cut their intake.

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• Evidence of Clinical Efficacy of Bebtelovimab in COVID-19

  In a retrospective study, bebtelovimab demonstrated efficacy similar to Paxlovid in high-risk outpatients with recent onset of COVID-19 who reported mild to moderate symptoms.

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• Importance of Medication Adherence in Ischemic Heart Disease

  The results of a subanalysis of the ISCHEMIA trial indicated about one-quarter of patients in both conservative and invasive strategy groups were nonadherent to recommended medical therapy at baseline. Nonadherence was associated with worse health status in both groups at baseline and after one year.

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• Vitamin D3, Omega-3 Supplements for Older Adults to Lower Frailty Risk

  Data from a large, randomized trial that included 25,871 adults age 50 years or older indicated 2,000 daily units of vitamin D3 and 1 g daily of omega-3 fatty acid supplementation did not affect frailty.

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• Increasing Incidence of Stage IV Cervical Cancer

  The incidence of stage IV cervical cancer in the United States between 2001 and 2018 increased. Rates were highest among Black women, but the annual rate of increase was highest among white women in the South age 40-44 years.

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• Deucravacitinib Tablets (Sotyktu)

  Deucravacitinib can be prescribed to adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.

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