Infectious Disease Alert – February 1, 2025
February 1, 2025
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Fidaxomicin Is More Clinically Effective than Vancomycin for C. difficile Infection
There is a lack of real-world data on using fidaxomicin for Clostridioides difficile infection (CDI). A retrospective, single-center study found that treatment of CDI with fidaxomicin leads to reduced clinical failure compared to oral vancomycin.
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Aeromonas Infections — Do Not Go Near the Water
Infection with Aeromonas mostly involves skin and soft tissue and traumatic wounds occurring with exposure to water contaminated by the organism. The organism often is resistant to carbapenems because of the presence of a chromosomal carbapenemase, while often remaining susceptible to third-generation cephalosporins.
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Procalcitonin-Guided Care Leads to Shorter Duration of Antibiotics in Sepsis Patients
In this multicenter, intervention-concealed, randomized clinical trial of 2,760 critically ill patients hospitalized with sepsis, the use of a daily procalcitonin-guided protocol resulted in shorter antibiotic duration as compared with standard care, without a significant difference in 28-day all-cause mortality. There was no significant difference in antibiotic duration between patients managed with a daily C-reactive protein-guided protocol and standard care, and the difference in all-cause mortality between these two groups was inconclusive.
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Unhurried Patient Care
Unhurried conversations during patient encounters can improve outcomes for patients and enhance career satisfaction of physicians. Specific communication strategies can foster unhurried conversations without adding undue time to clinical care.
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Infectious Disease Updates
Clostridioides difficile: Reduced Susceptibility to Vancomycin? Antibiotics Reduce Culture Yield in Joint Infection