Critical Care Alert – March 1, 2024

March 1, 2024

• Ventilation and Oxygenation Considerations During and After Cardiopulmonary Resuscitation

  With a multitude of recommendations spanning from monitoring during cardiopulmonary resuscitation (CPR) to post-arrest targeted temperature management, the specific focus of this article is to review considerations related to ventilation and oxygenation during and after CPR.

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• Does Alkaline Phosphatase Reduce Sepsis-Associated Acute Kidney Injury?

  This Phase III, international, multicenter, double-blind, randomized controlled trial did not show a reduction in 28-day all-cause mortality with ilofotase alfa (recombinant human alkaline phosphatase). However, the study showed evidence to suggest that ilofotase alfa reduced major adverse kidney events at 90 days, mainly driven by lowering the incidence of renal replacement therapy through day 90 in these patients.

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• ICU Delirium Linked to Post-Discharge Change in Cancer Treatment and Higher Mortality Among Cancer Patients

  In this single-center, retrospective cohort study, intensive care unit (ICU) delirium was associated with a higher rate of cancer treatment modification, only partly due to worsening performance status, after discharge and higher one-year mortality.

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