Critical Care Alert – April 1, 2024
April 1, 2024
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Norepinephrine Can Be Infused Safely Via Peripheral IV Catheter
Peripheral administration of norepinephrine has a low risk of extravasation if following an operationalized protocol.
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High-Flow Nasal Oxygen for Acute Hypoxemic Respiratory Failure Due to COVID-19 Is Safe Initiated Outside the ICU
This study of hospitalized adults with COVID-19-related hypoxemic respiratory failure found that initiation of high-flow nasal oxygen on the wards was safe, resulted in comparable intubation and mortality rates, and led to less time in the intensive care unit.
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Low-Dose vs. Conventional-Dose TMP-SMX to Treat Pneumocystis Pneumonia in Non-HIV Patients
In patients without human immunodeficiency virus who were diagnosed with Pneumocystis jirovecii pneumonia, mortality rates were similar between the low-dose vs. conventional-dose trimethoprim-sulfamethoxazole (TMP-SMX) groups, while low-dose TMP-SMX was associated with fewer adverse events.
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Withholding Intubation in Select Comatose Patients with Acute Poisoning May Be Beneficial
In this unblinded, randomized trial of adults presenting with acute poisoning and a Glasgow Coma Scale score less than 9, those for whom intubation was withheld unless emergently indicated had decreased intensive care unit and hospital lengths of stay and a lower rate of pneumonia.