Oral Penicillin Challenge Found to Be Noninferior to Skin Testing Followed by Oral Challenge in Low-Risk Patients with Reported Penicillin Allergy

A multicenter, randomized clinical trial that compared direct oral penicillin challenge in low-risk patients to skin testing followed by oral challenge found no significant differences. Direct oral penicillin challenge appears to be a safe and effective way to delabel a penicillin allergy.