Articles Tagged With: Sepsis
-
Why IDSA Did Not Support the Surviving Sepsis Campaign
The Infectious Diseases Society of America withheld its support for the Surviving Sepsis guidelines. The general concerns included vagueness and inconsistency in definition of sepsis, “one size fits all” prescription of time to administer antibiotics, lack of clarity around drawing blood cultures through IV catheters, recommendation of combination antibiotics, lack of definition around when to use procalcitonin levels, when and how to use pharmacokinetic and pharmacodynamic data effectively, prolonged antibiotic “prophylaxis,” and duration of therapy.
-
SIRS Criteria vs. qSOFA for Predicting Short-term Mortality From Sepsis
A meta-analysis that included 38 studies found the SIRS criteria had a higher sensitivity than qSOFA in predicting short-term mortality from sepsis. SIRS criteria remain useful as a screening tool for sepsis and as a prompt to initiate diagnostic work-up and treatment.
-
Recognizing Pediatric Sepsis: Early Diagnosis Critical to Recovery
Identifying pediatric sepsis and treating it quickly can be a matter of life and death.
-
Pediatric Sepsis and Septic Shock
Pediatric sepsis is a high-stakes diagnosis that requires vigilance to make an early, timely diagnosis. Aggressive resuscitation, including fluids, antibiotics, and vasoactive agents, may be necessary. Rapidly changing standard of care also makes sepsis a critical diagnosis for clinicians.
-
2016 Surviving Sepsis Guidelines Update
The Surviving Sepsis Campaign recently published an update to the 2012 guidelines for management of sepsis and septic shock. The document incorporates literature published through July 2016.
-
Sepsis Management: What We Think We Know
In the Protocolized Resuscitation in Sepsis Meta-Analysis (PRISM), 3,723 patients’ outcomes from the ProCESS, ARISE, and ProMISe randomized, controlled trials of early goal-directed therapy (EGDT) were evaluated. EGDT did not result in better outcomes than usual care and was associated with higher costs. The authors of a second study looked at outcomes of 49,331 patients with sepsis treated in New York from April 2014 to June 2016. More rapid completion of the three-hour sepsis bundle and antibiotic administration (but not rapid bolus administration of IV fluids) was associated with reduced in-hospital mortality.
-
Surviving Sepsis Campaign Guidelines Bundle: Studying How Improved Compliance Might Affect Outcomes
Improved compliance with the Surviving Sepsis Campaign guidelines bundle was associated with a non-statistically significant decrease in the in-hospital mortality of severe sepsis patients.
-
Clinicians Are Skeptical of Early Warning Systems for Sepsis
While early warning systems for sepsis lead to clinical action, clinicians are skeptical and do not perceive them to be beneficial.
-
Sepsis Resuscitation and Mortality
The use of balanced salt solutions rather than isotonic saline or colloids may improve in-hospital mortality in patients admitted with septic shock.
-
Hospital’s sepsis QI program lead to drop in mortality rate
There are many good reasons for a quality manager to focus on sepsis data collection and quality improvement, but the most important one is that patients — even those who were recently in optimal health — can die from sepsis if it’s not diagnosed early.