Articles Tagged With: Sepsis
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The Importance of Taking Blood Cultures Prior to Antibiotic Delivery in Sepsis Patients
While taking blood cultures should not significantly delay needed treatment, investigators noted their data prove that cultures taken post-treatment lose nearly half the clinical information needed to make subsequent treatment decisions.
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Temperature Trajectories to Find Sepsis Subphenotypes
The authors of this study used development and validation cohorts to retrospectively identify temperature trajectories over the first 72 hours from presentation in the setting of sepsis. Patients presenting with hyperthermia that resolved quickly (within the first 24 hours) had lower mortality compared to those with slow resolution or those presenting with hypothermia.
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It Was Too Early to Detect Sepsis: Can Defense Team Prove It?
Sepsis is not always diagnosable, or even present, at the time of an ED visit. All testing performed in the ED may provide negative results. Despite these facts, plaintiffs still may prevail in a missed sepsis lawsuit. -
Sepsis Can Begin With a Single Infection
The goal of antibiotic stewardship is to stop unnecessary use, but for those with sepsis, a critical step is to assess antibiotic therapy 48 to 72 hours after initiation.
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Impact of Early Low-Dose Norepinephrine in Adults Experiencing Sepsis With Hypotension
Adult patients experiencing sepsis with hypotension but who did not meet the definition of septic shock received a median of 800 mL of intravenous fluid prior to initiation of norepinephrine 0.05 mcg/kg/min as a non-titratable infusion. Patients in this early vasopressor group had much lower odds of failing to achieve their primary outcome of adequate mean arterial pressure and tissue perfusion when early norepinephrine was provided.
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Corticosteroid Administration in Sepsis May Be Associated With Lower 28-Day Mortality
In this systematic review and meta-analysis of randomized, controlled trials comparing administration of corticosteroids with placebo or standard supportive care in sepsis, corticosteroids were associated with reduced 28-day mortality.
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Evaluation and Treatment of Adrenal Insufficiency in the Emergency Department
This article addresses the pathophysiology, discusses various clinical presentations, and reviews current evidence-based practices for managing adrenal insufficiency and crisis in the emergency department.
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Antibiotic Decision-Making Between Medical and Surgical Teams
In an observational study conducted at an academic medical center in London, researchers looked at factors involved in decision-making. The presumptive diagnosis of infection by the emergency department (ED) influenced decision-making by both medical and surgical admitting teams. Medical teams tended to use a multidisciplinary approach to antibiotic decision-making. Surgical teams often delegated antibiotic decision-making to the most junior members of the surgical team.
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Severe Sepsis and Septic Shock Early Management Bundle
When the Severe Sepsis and Septic Shock Early Management Bundle was used to identify patients with severe sepsis or patients in septic shock, delays in lactate measurements for patients with abnormal lactate levels were associated with delayed initiation of antibiotic therapy and increased mortality.
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Re-evaluating Steroid Therapy in Septic Shock
Two recent trials have provided more data regarding steroid therapy for septic shock.