Articles Tagged With:
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Intravenous Tenecteplase for Stroke After 4.5 Hours Does Not Improve Outcome
The TIMELESS study was developed to evaluate the effect of treatment with tenecteplase 4.5 to 24 hours after stroke onset in patients with large artery occlusion who subsequently would go on to endovascular thrombectomy.
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Does Needle EMG Interfere with MR Neurography or Myography Interpretation?
In this carefully designed prospective clinical study, needle electromyography did not have any significant effect on the interpretation of magnetic resonance (MR) neurography or MR myography or alter the diagnosis.
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Longitudinal Follow-Up of Patients with Anti-NMDA Receptor Encephalitis
In this retrospective, observational study of 38 patients with autoimmune encephalitis, using standard clinical assessment rating scales, the only predictor of poor outcome was muscle weakness at symptom onset. Most patients had long-term problems with cognitive and mood disorders.
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Post-Operative Delirium May Involve Altered Brain Glucose Metabolism
Post-operative delirium is a major health problem that occurs in about half of older patients who undergo surgery with general anesthesia. This prospective study from Norway of patients undergoing emergency hip repair surgery demonstrated from spinal fluid analysis that patients with delirium have abnormalities in brain glucose uptake and metabolism and have an early shift to ketosis in the spinal fluid.
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Diagnosis and Management of Acute Heart Failure in the Emergency Department
This article will focus on the care of patients with acute heart failure in the emergency department, reviewing new onset and decompensation of chronic heart failure, discussing heart failure classification based on clinical presentation, and providing updated recommendations on management and disposition from the emergency department.
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Infectious Disease Alert Updates
The Burden of Clostridioides difficile Infection; The Globe May Be Warming, but People Are Cooler; Methotrexate for Chikungunya Arthritis
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Avian Flu Rears Its Beak Again in the United States
The Centers for Disease Control and Prevention has issued an alert after a human infection with highly pathogenic avian influenza (HPAI) A(H5N1) virus in the United States following exposure to presumed infected dairy cattle. No human-to-human transmission of HPAI A(H5N1) virus has been identified.
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Nirmatrelvir-Ritonavir in High-Risk Vaccinated and Low-Risk Unvaccinated Participants: The EPIC-SR Trial
In this Phase II-III randomized controlled clinical trial (EPIC-SR), nirmatrelvir-ritonavir was not associated with a significant difference in time to alleviation of symptoms nor COVID-19-related hospitalization or death from any cause as compared with placebo in unvaccinated individuals without risk factors for severe disease or in vaccinated individuals with a least one risk factor for severe disease.
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High-Mortality Cryptococcosis Infection After COVID-19
A survey initiated by the Mycoses Study Group identified 69 cases of cryptococcosis following COVID-19 infection. The mortality rate was 59%, with cases in both immunocompromised and immunocompetent individuals.
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Meningococcal Disease Is on the Rise
The number of cases of infection with Neisseria meningitidis is increasing in the United States. The majority of presentations are with bacteremia; meningitis is infrequent.