Articles Tagged With:
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Adverse Neurological Events from Immune Checkpoint Inhibitors
Immune checkpoint inhibitors have transformed the natural history of many metastatic cancers and now are widely used. However, the activation of killer T-cells also has caused serious, often fatal complications from the treatment. The central nervous system is a common victim of these complications.
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What Is the Best First-Line Treatment for Young Women with Generalized Epilepsy?
Valproate is a highly efficacious drug for treating idiopathic generalized epilepsy (IGE) but is not an option for many young women because of known teratogenic risks. This retrospective, multicenter study examined women with IGE who were treated initially with either levetiracetam or lamotrigine monotherapy, demonstrating superior efficacy of levetiracetam, although exclusively in women with juvenile myoclonic epilepsy.
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Searching for Step Counts: Defining Goals for Daily Exercise
A systematic review and meta-analysis of studies of the association of step counts and cadence with all-cause mortality and cardiovascular events showed the benefits in these outcomes are statistically significant, at about 2,600 steps/day and peak at about 8,000 steps/day. Also, faster step cadence augments these benefits.
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Can Turmeric Help Handle Heartburn?
In a randomized controlled trial, curcumin demonstrated comparable efficacy to omeprazole in treating dyspepsia and acid reflux.
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Empowered Relief vs. CBT vs. Health Education for Low Back Pain
This randomized clinical trial involving adults with chronic low back pain demonstrates that a single session of a pain management class, when compared to a full course of cognitive behavioral therapy, yields noninferior (clinically on par) outcomes in pain catastrophizing and several other measures at the three-month follow-up.
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Double Trouble: Vaccines Lag, Virulent Mpox Clade 1 Spreads
The Centers for Disease Control and Prevention has released two health advisory alerts only a week apart, one dealing with the “urgent need” to vaccinate people for seasonal respiratory viruses; the second warning that a virulent type of mpox (monkeypox) virus is spreading in Africa.
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The IP Role in Sepsis
The Centers for Disease Control and Prevention has issued core elements for hospital sepsis programs, calling for a multidisciplinary team to prevent, detect, and treat these life-threatening systemic breakdowns.
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MRSA: Isolation and Contact Precautions Still Needed?
The authors of a new study question the merits of isolation and contact precautions for patients with methicillin-resistant Staphylococcus aureus.
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Pandemic Raises Spectre of Bioterror
The three-year viral storm of COVID-19 circling the globe and killing millions of people has left a lingering question: Has the wholesale disruption and devastation of SARS-CoV-2 made biological pathogens a more compelling and/or attainable goal by bioterrorists?
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The Seeker: Infection Control Doctor Takes the Road Less Traveled
Meet Leighann Parkes, MD, FRCPC, medical officer for infection prevention and control at McGill University in Montreal, who took a decidedly circuitous route to understanding and preventing infections.