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Hot Trials from the European Society of Cardiology Annual Congress
Below are some highlights from four key studies presented in Barcelona, Spain, between Aug. 26 and Aug. 29, 2022, along with Dr. Crawford’s personal commentary on each.
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Betibeglogene Autotemcel Suspension (Zynteglo)
The FDA has approved the first cell-based gene therapy to treat adult and pediatric patients with beta-thalassemia who require regular blood transfusions.
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Remaining Questions in Syphilis Treatment
Eight leading experts on sexually transmitted diseases convened to discuss key questions in the management of syphilis in adults with and without HIV infection based on a systematic review of the literature. More than 3,000 articles were screened, and the discussion focused on 95 relevant publications and three main topics.
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Appropriate Management of Thoracic Aortic Aneurysms
Among patients with arch and descending thoracic aorta aneurysms followed over a mean of 20 months, aneurysm-related mortality was predicted by the size and growth rate of the aneurysms, along with age and sex.
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Predicting the Tolerability of Sacubitril/Valsartan in Advanced Heart Failure
An analysis of the sacubitril/valsartan run-in period for chronic, advanced heart failure patients showed 18% could not tolerate the lowest dose, usually because of hypotension or renal dysfunction. Investigators identified six predictors of non-tolerance, which may help clinicians choose the best candidates.
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An Unhealthy Gut Microbiome May Cause Colorectal Cancer
An E. coli variant found in the Western diet was associated with a higher incidence of colorectal cancer.
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Treatment of Acute Vertigo
Treating acute vertigo with an antihistamine was more effective than benzodiazepines for acute symptoms. However, there was no difference between the two medications in terms of resolution within one week or one month.
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Research Shows Pharmacists Can Easily Dispense Medication Abortion
The results of a recent study support allowing pharmacists to dispense mifepristone directly to people — like any other medication.
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Declining Pregnancy Among U.S. Teens Partly Due to Contraceptive Changes
Pregnancies and births in young people, ages 14 to 18 years, have declined dramatically in recent years when compared to decades past, new research shows. Researchers studied data from 2007 to 2017 and found that delays in first sexual intercourse contributed the most to the trend of declining births over this decade. But declines in the number of sexual partners and changes in contraceptive use — including use of long-acting reversible contraception — also contributed to the trend.
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Self-Administered Depo-Provera Improves Use and Efficacy
Depo-Provera is a convenient option for patients who want a contraceptive that is both effective and can last for several months. But one drawback is that it requires a clinic visit for an injection. This is where an option to self-administer Depo could improve access to and continuation of the contraceptive.