Articles Tagged With:
-
Targeting Vasomotor Symptoms with a Neurokinin-3 Receptor Antagonist
A meta-analysis of five randomized controlled studies showed that fezolinetant improved moderate-to-severe vasomotor symptoms with a pooled mean difference of 2.62 episodes per day (95% confidence interval [CI], 1.85-3.41) and had no significant adverse effects compared to placebo (odds ratio, 1.01; 95% CI, 0.84-1.22).
-
Safety of Non-Insulin Antidiabetic Medications in Early Pregnancy
A multinational cohort study of more than 50,000 pregnant people found that those with periconceptual use of non-insulin antidiabetic medications, such as sulfonylureas, dipeptidyl peptidase 4 inhibitors, glucagon-like peptide 1 agonists, or sodium-glucose cotransporter 2 inhibitors, did not have increased risk of congenital malformations compared to those who used insulin periconceptually.
-
Scarlet Fever and Invasive Streptococcal Disease
While most physicians are familiar with the common presentations of streptococcal infections (e.g., pharyngitis, impetigo), it is important to recognize the carrier state, learn management of common complications (e.g., peritonsillar abscess), and identify the potentially serious, and perhaps deadly, complications and invasive infections.
-
A Run of Aberrant AFib?
The patient whose electrocardiogram (ECG) appears in the figure is a previously healthy man who presented to the emergency department because of acute dyspnea. What is the cause of the run of wide beats?
-
Aprocitentan (Tryvio)
The U.S. Food and Drug Administration (FDA) has approved a first-in-class endothelin receptor antagonist for the treatment of high blood pressure not adequately controlled with other antihypertensives.
-
The Globe May Be Warming, but People Are Cooler
What is normal? Patients like to tell me their normal temperature is “not normal.” Our idea of a normal temperature came from the work of a German physician who screened 25,000 patients and concluded in an 1868 publication that the normal human body temperature was 98.6°F. That number has stuck with us for 150 years. Are people now cooler?
-
Rapid Reversal of Anticoagulation Reduces Mortality from Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is the deadliest type of stroke. ICH associated with anticoagulation carries an even higher mortality. Serial imaging studies have demonstrated that there is significant hematoma enlargement during the first few hours after arrival at the hospital, and this also portends a poor outcome.
-
Stress Reduction for Physicians — What Works?
A randomized controlled study of 129 physicians demonstrated that a two-month regimen of sudarshan kriya yoga, incorporating stretching, breathing, and meditation, is associated with reduced stress, anxiety, and depressive symptoms when compared to conventional stress management training.
-
Does Calcium Intake Cause Cardiovascular Disease?
A large population study of calcium intake at dinner vs. breakfast showed an increased risk of heart disease.
-
Nonaccidental Trauma
Nonaccidental trauma is a significant problem in emergency medicine and serves as the frontline of defense and protection for children. All providers must have a high degree of suspicion for the sometimes subtle presentation of an abused child. Early diagnosis and timely intervention are the only ways to allow these vulnerable children a chance at a normal, healthy life.