Articles Tagged With:
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Turmeric (Curcumin) Helps Patients with Dyspepsia and Acid Reflux
In a randomized, controlled trial, curcumin demonstrated comparable efficacy to omeprazole in treating dyspepsia and acid reflux.
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Treating Preclinical Alzheimer’s Disease
After studying an anti-amyloid antibody, solanezumab, researchers reported there was no benefit in reducing the likelihood of progression of cognitive impairment in patients with positive amyloid PET scans who started the trial cognitively unimpaired, compared to placebo.
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Is the Combination of a GLP-1 Agonist and a SGLT2 Inhibitor Safe?
An analysis of the Harmony Outcomes study and a meta-analysis combining it with the AMPLITUDE-O study of the addition of a glucagon-like peptide 1 receptor agonist (GLP-1 RA) in a subgroup of type 2 diabetes patients on baseline sodium-glucose cotransporter-2 (SGLT2) inhibitor therapy has shown that major adverse cardiovascular events are reduced by GLP-1 RA, regardless of baseline SGLT2 use, and there was no difference in serious adverse events.
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An RNA Shot for Hypertension?
One dose of a new RNA-based drug administered by subcutaneous injection, which blocks hepatic angiotensinogen production, resulted in sustained reductions in blood pressure in patients with hypertension for up to 24 weeks without any serious adverse effects.
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Canakinumab Injection (Ilaris)
Canakinumab can be prescribed to adults with gout in whom nonsteroidal anti-inflammatory drugs and colchicine are contraindicated, are not tolerated, or do not provide an adequate response, and in whom repeated courses of corticosteroids are not appropriate.
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New Ethical Guidance on Pediatric Decision-Making
According to the recommendations, ethical decision-making can factor in parents’ consideration of the child’s non-health interests (e.g., a child’s interest in playing football, even if it risks concussions), and also may consider the interests of other family members, provided those do not severely compromise the child’s health.
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Many Ethics Committees Are Not Following AAP Guidance
In a survey of ethics consultant leaders at children’s hospitals, researchers found multiple practice gaps, including training needs; informing staff, patients, and family about ethics services; and scope of ethics service. These practice gaps could erode ethics quality and narrow ethics reach.
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Early, Integrated Education May Prevent ‘Ethical Erosion’
Modalities such as ethics rounds or shadowing could help make these considerations a part of everyday practice.
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Conflicts of Interest Are Prevalent in Clinical Guidelines
Even the appearance of bias in clinical practice guidelines is problematic, since it could diminish public trust in medicine. Ensuring there are functioning systems in place to keep practice guidelines objective and free of this influence must be a priority.
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When Surrogate Decision-Makers Misunderstand Patients’ Condition
In the view of clinicians, surrogates of patients with higher acuity of illness could better understand the clinical situation. However, those surrogates might be less likely to correctly identify all the affected organ systems. Surrogates who seem to strongly grasp the situation may not actually feel as secure in their understanding.