Articles Tagged With:
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Donanemab-azbt (Kisunla)
The U.S. Food and Drug Administration has approved the third anti-amyloid beta monoclonal antibody for the treatment of Alzheimer’s disease, following aducanumab and lecanemab.
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Dengue Is Surging, Including in the Americas
Dengue is surging, and cases have been acquired in the United States, including in Puerto Rico and Florida.
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CVD Risk from Ketogenic Diets
A recent analysis of the UK Biobank data found that subjects on a low-carbohydrate, high-fat diet had higher levels of low-density lipoprotein cholesterol and apolipoprotein B, and an increase in incident major adverse cardiovascular events over a 12-year follow-up than subjects on a standard diet.
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Comparing Antidepressants’ Effects on Weight Gain
This observational study finds that, compared to sertraline, six-month weight gain is higher in patients prescribed other antidepressants in the same category (paroxetine, citalopram, escitalopram) as well as in patients prescribed duloxetine and venlafaxine, similar in patients prescribed fluoxetine, and lower in patients prescribed bupropion.
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Concussion Assessment in the Emergency Department with an Emphasis on Sports-Related Injury
The body of research regarding concussions has broadened dramatically in recent years. This expanded medical knowledge has led to changes in the recommended treatment of concussion. It is important for emergency medicine physicians to be well versed in the recognition and management of concussion in the emergency department, as well as potential complications and long-term sequelae of this condition.
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Is Endomyocardial Biopsy Still Necessary if Cardiac MRI Is Available?
A multicenter registry study in Europe of patients with suspected myocarditis has shown that, compared to cardiac magnetic resonance imaging, endomyocardial biopsy still is the gold standard, and lower ejection fraction and need for immunosuppressant drugs predicted a worse outcome.
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Outcomes of Low-Risk Bicuspid Aortic Valve Patients Undergoing TAVR
In this prospective, multicenter, single-arm trial, low-surgical risk patients with bicuspid aortic valve anatomy treated with transcatheter aortic valve replacement showed favorable results at three years, with low rates of death and disabling stroke.
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Is Anticoagulation Necessary for Post-CABG Surgery Atrial Fibrillation?
A meta-analysis of non-randomized trials of oral anticoagulant use for new atrial fibrillation (AF) after coronary artery bypass surgery involving almost 1.7 million patients has shown that AF is frequent, but the incidence of thromboembolism, bleeding, and death are low. Oral anticoagulants, when given, do not significantly affect thromboembolism or mortality rates, but they do increase bleeding.
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Indications for Reduced-Dose Direct Oral Anticoagulants
A subgroup analysis of the ENGAGE-AF TIMI 48 study of edoxaban 60 mg/day vs. 30 mg/day compared to warfarin in patients with atrial fibrillation of the group 80 years of age or older has shown that 30 mg/day results in less major bleeding without a concomitant increase in stroke risk compared to 60 mg/day or warfarin.
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Are Mineralocorticoid Receptor Antagonists Safe in Heart Failure Patients with Renal Dysfunction?
A post hoc analysis of the RALES and EMPHASIS HF trials has shown that, although treatment of heart failure with reduced left ventricular ejection fraction patients with mineralocorticoid receptor antagonists can cause a significant deterioration in renal function, the benefits outweigh the adverse effects and should not lead to automatic therapy discontinuation.