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  • Blood Culture-negative Endocarditis: What Can the Laboratory Bring to the Table?

    Several years ago, two different publications appeared showing that prolonged incubation of blood cultures beyond the initial five-day protocol for patients with suspected fastidious bacterial endocarditis did not yield significant additional pathogens with today's modern blood-culture media and automated methods.
  • Malaria Surveillance in the United States

    Malaria continues to be a global scourge, with nearly half the world's population living in malaria-endemic areas, 200-500 million annual clinical cases, and nearly a million annual deaths (almost all due to P. falciparum).
  • Pharmacology Watch: Aggressive Modification of Cardiovascular Risk Factors

    In this issue: Aggressive approach to CVD reduces MI, folic acid and vitamin B12 for CAD, corticosteroids for acute exacerbations of COPD, prescription drug abuse among young adults, and ARBs and cancer risk.
  • Updates By Carol Kemper, MD, FACP

    Since the release of initial CDC guidelines in 2005 for using the Quanti-FERON-TB Gold test, two additional interferon gamma-release assays (IGRAs) have been approved by the FDA, bringing the number of tests for detecting tuberculosis (TB) infection used in the United States to four.
  • Breast-feeding Reduces Risk of Infectious Diseases

    A prospective, population-based cohort study was conducted from 2002-2006 in the Netherlands of 4,164 children during the first year of life, and included questionnaires and physician-confirmed infections of the upper respiratory tract (URT), lower respiratory tract (LRT), and gastrointestinal tract (GI).
  • Mitochondrial Toxicity of Ribavirin and HAART Correlates with Virological Response of HCV in HIV/HCV Co-infected Patients

    Data for 64 HIV/HCV co-infected patients treated in a prospective study of pegylated IFN alpha + RBV were analyzed. IFN was administered at 180 mcg SQ/week and RBV was dosed at 800 mg daily for patients with HCV genotype 2 or 3 and 1,000-1,200 mg/day for the first 12 weeks in patients with genotype 1 or 4, then reduced to 800 mg/day until completion of therapy.
  • News Briefs

    The Centers for Disease Control and Prevention which erred on the side of caution and consternation for infection preventionists during the flu pandemic now concedes surgical masks are sufficient to protect health care workers against H1N1 influenza A. Draft guidelines for seasonal influenza downgrade the controversial recommendation to wear N95 respirators.
  • New blood: APIC seeks to embrace 'diverse views'

    In a discussion that goes well beyond the implied semantics of a simple name change, the Association for Professionals in Infection Control and Epidemiology (APIC) continues to try to define its "brand" in a rapidly changing marketplace.
  • Linking best practices, electronic surveillance

    Hospitals that adopt advanced computer technology to identify healthcare-associated infections (HAIs) are more likely to have implemented best practices to prevent such infections, according to research presented recently in New Orleans at the annual conference of the Association for Professionals in Infection Control and Epidemiology (APIC).
  • Obama warns of 'declining sense of urgency' on HIV

    Editor's note: As this issue of AIDS Alert was going to press, the White House released its National HIV/AIDS Strategy. The is summarized as follows. Look to future issues of AIDS Alert for analysis and updates on plan.