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In a multicenter, randomized, double-blind, placebo-controlled clinical trial of bevacizumab added to standard temozolomide and radiation therapy for patients with glioblastoma multiforme, progression-free survival but not overall survival was enhanced.
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In a well-controlled retrospective analysis of patients who presented with metastatic colorectal cancer, primary tumor resection was associated with improved overall survival.
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Bevacizumab added to chemotherapy, particularly paclitaxel and cisplatin, was efficacious in all response outcomes (objective response, progression-free survival, and overall survival) without diminution in quality of life or unacceptable toxicity.
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Indemnification clauses included in some contracts with employers, hospitals, and payers can complicate malpractice litigation and can result in additional liability for physicians.
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A physician has complied with the standard of care if he or she chooses any of the reasonably acceptable options in a given situation.
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Successful malpractice suits can result even if a patient refused a treatment or test.
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A common allegation in malpractice claims is that a patient has a significant incidental finding on an imaging study, but is never informed of it and does not receive treatment for it on a timely basis.
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Over-reliance on information provided by patients presents legal risks for physicians, as patients might give inaccurate, misleading information for multiple reasons.