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Update on Treatments for Vulvovaginal Atrophy
Vulvovaginal atrophy, now known as the genitourinary syndrome of menopause (GSM), occurs with the decline of estrogen in the menopausal period. As with many clinical conditions, the spectrum of GSM requires the clinician to consider the effect on the patient’s quality of life. Although many symptoms are pacified effectively with situational lubricants and regular moisturizers, local estrogen is a safe, effective, and affordable way to treat the vulvovaginal changes of menopause.
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Infertility Therapy Leads to Increased Risk of Severe Maternal Morbidity
Women undergoing infertility treatment, particularly in vitro fertilization, are at higher risk of severe maternal morbidity, but the overall risk remains low.
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Predicting Recurrence After Pelvic Organ Prolapse Surgery
SYNOPSIS: Prediction models can provide helpful information regarding the risk of recurrence after prolapse surgery.
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Ultrasound vs. MRI in Diagnosis of Placenta Accreta
The authors of this two-center study found that magnetic resonance is not superior to ultrasound in diagnostic accuracy for placenta accreta spectrum disorders, and its usefulness is tempered particularly by a tendency to falsely upgrade the stage of severity.
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Acute Treatment of Pediatric Migraine
Migraines occur in young children, but may be challenging to diagnose. Migraines can have a great impact on pediatric patients’ quality of life with school absence and limitations on extracurricular activities. Treatment of pediatric migraines or possible migraines is difficult secondary to the lack of evidence for effective therapies in pediatric patients. Treatment includes traditional therapy with dopamine receptor antagonists (DRAs), nonsteroidal anti-inflammatory drugs (NSAIDs), triptans, and combination therapies. Newer therapies include magnesium, valproic acid (VPA), and peripheral nerve blocks. The authors review the clinical presentation of migraines in children, guidelines for diagnosis, and therapeutic options.
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Infectious Disease Alert Updates
Imagine: Multidrug-Resistant GC; A New Borrelia Species in the ‘Old World’
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Baloxavir Marboxil (Xofluza)
Baloxavir marboxil is a novel, oral, antiviral agent approved by the Food and Drug Administration (FDA) on Oct. 24, 2018, for the treatment of acute uncomplicated influenza in patients 12 years of age and older.
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Staphylococcus aureus on the Playground and in the Gym — Is It Inescapable?
Staphylococcus aureus, including methicillin-resistant S. aureus, is a frequent surface environmental contaminant on both children’s playgrounds and in adult fitness centers.
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Adenovirus and CNS Disease in Children
Forty-eight immunocompetent children with adenovirus-associated central nervous system disease were described. Thirty-eight percent of patients died or experienced permanent neurologic sequelae.
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Sleep Tight, Don’t Let the Mucorales Bite
Mucorales were found to commonly contaminate linen delivered to 15 transplant and cancer centers in the United States.