Articles Tagged With:
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Treatment of Progressive Multifocal Leukoencephalopathy With Pembrolizumab
These authors evaluated the effect of pembrolizumab, a monoclonal antibody that functions as a down-regulator of PD-1 (programmed cell death protein 1), on patients with progressive multifocal leukoencephalopathy. In five of eight treated patients, clinical stabilization or improvement was seen in association with reduced cerebrospinal fluid JC viral load. This is the first reported effective treatment for this disease with a therapeutic agent targeting the JC virus.
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Tau PET Is Promising as a Diagnostic Agent in Chronic Traumatic Encephalopathy
Former NFL players with symptoms consistent with chronic traumatic encephalopathy had increased tau tracer uptake that was associated with years of playing football but not with cognitive or neuropsychological measures.
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Tau PET Is Promising as a Diagnostic Agent in Chronic Traumatic Encephalopathy
Former NFL players with symptoms consistent with chronic traumatic encephalopathy had increased tau tracer uptake that was associated with years of playing football but not with cognitive or neuropsychological measures.
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Late Sunsets, Sleep Deprivation, and Adverse Outcomes
All living organisms have 24-hour circadian rhythms. A body of evidence is accumulating that chronic disruption of this important rhythm may result in poor health outcomes. These negative consequences of disrupted circadian rhythms might be prevented by modifying work and sleep schedules.
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Neuropathy in Systemic Lupus Erythematosus
Systemic lupus erythematosus may be associated with a variety of neuropsychiatric syndromes, including peripheral neuropathy, mostly sensorimotor types. However, all parts of the peripheral and central nervous system may be affected, and careful and repeated neurological evaluation is important.
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Eculizumab Shows Benefit in a Treatment Trial of NOSD
In a randomized, placebo-controlled trial of aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorders, eculizumab demonstrated a decrease in the risk of a relapse. Patients could continue their other stable-dose immune suppressive therapies while enrolled in the trial.
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Osteoporosis Review
Osteoporosis is a skeletal disorder in which bone density and quality are reduced. Patients experience loss of bone mass, deterioration of bone tissue, and a decline in bone quality, which leads to increased bone fragility and a higher risk of fractures. It is imperative that primary care providers address this challenge by implementing practices to screen patients for onset of osteoporosis to prevent and/or treat the disorder.
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HHS 'Conscience Rule' Sparks Ethical Debate
Some argue the rule will protect physicians, but will it lead to discrimination against patients?
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Few Cardiology Treatment Recommendations Based on High-Quality Evidence
The proportion of recommendations supported by data from randomized controlled trials actually decreased from 2008. In looking at updated guidelines, the researchers found that fewer recommendations were supported by randomized controlled trials than in the prior versions.
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Ethics of Cellphone Use in Clinic Waiting Rooms
Ethical issues related to patient cellphone use center around the physician-patient relationship. At issue: How to balance the value of both physicians’ and patients’ time.