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The multicenter, unsustained tachycardia trial (MUSTT) was a randomized clinical trial designed to test whether antiarrhythmic therapy guided by electrophysiologic testing would reduce arrhythmic death and total mortality in high-risk patients.
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Iwai and colleagues evaluated the effects of adenosine in 42 patients who underwent an electrophysiologic study and radiofrequency ablation for recurrent atrial tachycardias.
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The pravastatin in elderly individuals at risk of vascular disease (PROSPER) trial is a study of statin therapy in high-risk elderly individuals. PROSPER tested the hypothesis that the benefits of statin therapy on cardiovascular disease, stroke, and cognitive decline would be seen in the elderly, which had not yet been rigorously investigated with respect to LDL lowering with a statin.
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Carotid artery stenting is an attractive concept for the treatment of patients with significant carotid stenoses who were at higher risk for carotid endarterectomy, but stroke rates in initial studies were unacceptably high.
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After years of legal wrangling, the FDA has approved loratadine (Claritin, Schering-Plough) as an over-the-counter (OTC) product for the treatment of seasonal rhinitis.
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The 12-month results of CREDO (clopidogrel for the Reduction of Events During Observation) were presented at AHA to coincide with the publication of this important clinical trial in the November 20, 2002, issue of JAMA.
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The Food and Drug Administration (FDA) has issued new guidance intended to assist sponsors in the clinical development of drugs for the treatment of HIV infection. Specifically, it addresses the FDAs current thinking regarding designs of clinical trials that use HIV ribonucleic acid (RNA) measurements to support accelerated and traditional approvals of antiretroviral drug products.
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A study conducted at San Francisco General Hospital suggests a greater incidence rate of severe psychiatric illness resulting from HIV treatment with efavirenz than what has previously been reported.
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Zandi and colleagues conducted a prospective study of incident dementia among 1357 men with a mean age of 73.2 years and 1889 women with a mean age of 74.5 years.
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Oz and colleagues recently re-explored the possible etiology of the oligohydramnios sometimes seen in post-term pregnancy.
