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  • Preventing Injurious Falls With Tai Ji Quan or Exercise in At-Risk Populations

    In this three-arm study, a therapeutic form of Tai ji quan is superior to either a multimodal exercise or a stretching program in reducing severe injurious falls among at-risk older, community-dwelling Americans.

  • Diet and Global Mortality

    Worldwide, there are alarming trends in unhealthy eating habits, which account for significant morbidity and mortality.

  • Procedural Sedation and Analgesia in the Emergency Department

    Procedural sedation and analgesia (PSA) is performed in the emergency department (ED) to alleviate anxiety, decrease pain, and provide amnesia to patients undergoing painful procedures or diagnostic imaging.This article will review guidelines for performing PSA in the ED, including suggested training, preprocedural assessment, and intraprocedural monitoring.

  • Treatment of Progressive Multifocal Leukoencephalopathy With Pembrolizumab

    These authors evaluated the effect of pembrolizumab, a monoclonal antibody that functions as a down-regulator of PD-1 (programmed cell death protein 1), on patients with progressive multifocal leukoencephalopathy. In five of eight treated patients, clinical stabilization or improvement was seen in association with reduced cerebrospinal fluid JC viral load. This is the first reported effective treatment for this disease with a therapeutic agent targeting the JC virus.

  • Tau PET Is Promising as a Diagnostic Agent in Chronic Traumatic Encephalopathy

    Former NFL players with symptoms consistent with chronic traumatic encephalopathy had increased tau tracer uptake that was associated with years of playing football but not with cognitive or neuropsychological measures.

  • Tau PET Is Promising as a Diagnostic Agent in Chronic Traumatic Encephalopathy

    Former NFL players with symptoms consistent with chronic traumatic encephalopathy had increased tau tracer uptake that was associated with years of playing football but not with cognitive or neuropsychological measures.

  • Late Sunsets, Sleep Deprivation, and Adverse Outcomes

    All living organisms have 24-hour circadian rhythms. A body of evidence is accumulating that chronic disruption of this important rhythm may result in poor health outcomes. These negative consequences of disrupted circadian rhythms might be prevented by modifying work and sleep schedules.

  • Neuropathy in Systemic Lupus Erythematosus

    Systemic lupus erythematosus may be associated with a variety of neuropsychiatric syndromes, including peripheral neuropathy, mostly sensorimotor types. However, all parts of the peripheral and central nervous system may be affected, and careful and repeated neurological evaluation is important.

  • Eculizumab Shows Benefit in a Treatment Trial of NOSD

    In a randomized, placebo-controlled trial of aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorders, eculizumab demonstrated a decrease in the risk of a relapse. Patients could continue their other stable-dose immune suppressive therapies while enrolled in the trial.

  • Osteoporosis Review

    Osteoporosis is a skeletal disorder in which bone density and quality are reduced. Patients experience loss of bone mass, deterioration of bone tissue, and a decline in bone quality, which leads to increased bone fragility and a higher risk of fractures. It is imperative that primary care providers address this challenge by implementing practices to screen patients for onset of osteoporosis to prevent and/or treat the disorder.