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  • Racial, Ethnic Disparities in Restraint Use

    Use restraints only when absolutely necessary, and in accordance with established protocols and regulations. Undergo training on appropriate restraint techniques. Ensure regular monitoring of restrained patients. Continuously reassess the need for restraints. Clearly document the rationale for restraint use.

  • EMTALA Concerns if Patients Ask About Delays

    Are discouraging comments an EMTALA violation? Investigators would examine factors such as what exactly was stated, under what circumstances the comment was made, whether the information was truthful and accurate, and whether it discouraged the patient from staying in the ED and receiving care.

  • Examining the Effect of Physical Activity and Depressive Symptoms in Adolescents

    In a robust meta-analysis of 21 studies, physical activity interventions showed a significant short-term benefit for children and adolescents with depressive symptoms, particularly in those aged 13 years and older and in participants with a diagnosis of depression.

  • Can Internet Use Prevent Dementia?

    In an ongoing longitudinal survey of a nationally representative sample of dementia-free adults age 50 to 64.9 years, regular internet users experienced approximately half the risk of dementia compared with non-regular users.

  • Searching for a Neuroprotective Agent in Celery Seed Oil

    A Phase III double-blind, placebo-controlled, randomized, controlled trial suggests that early administration of DL-3-n-butylphthalide, when given adjunctively to thrombolysis or endovascular therapy, improves functional outcomes in patients with acute ischemic stroke. Statistically significant results of well-designed analyses are tantalizing, but confidence in the findings is tempered by a lack of generalizability, an unclear mechanism of action, and trial design irregularities.

  • Biomarker Profiles of Those Living to Age 100 Years

    Among 1,224 participants who lived to their 100th birthday, there were higher levels of total cholesterol and iron, and lower levels of glucose, creatinine, uric acid, liver enzymes, and alkaline phosphatase compared with non-centenarians. These differences were seen as early as age 65 years.

  • The Hemodynamic Effects of an SGLT2 Inhibitor in Heart Failure with Preserved Ejection Fraction

    The authors of a small, placebo-controlled study of 24 weeks of dapagliflozin therapy in patients with heart failure with preserved ejection fraction reported reductions in pulmonary capillary wedge pressure, which may explain the reductions in heart failure hospitalizations or cardiovascular death in larger randomized outcome trials.

  • Major Cardiovascular Event Risk Reduction with Pitavastatin in Patients Living with HIV

    Among participants living with HIV who are at low-to-moderate risk for cardiovascular disease, those who received pitavastatin were 35% less likely to experience a major adverse cardiovascular event over a follow-up of approximately five years vs. those who received placebo.

  • Momelotinib Tablets (Ojjaara)

    Momelotinib can be prescribed to treat intermediate- or high-risk myelofibrosis.

  • Aberrant Conduction?

    How should one interpret the ECG in the figure? Is the rhythm most likely to be a re-entry supraventricular tachycardia with aberrant conduction?