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Are SGLT2 Inhibitors Effective for HFpEF Patients Without Diabetes?
After comparing empagliflozin vs. placebo for patients with heart failure and preserved left ventricular ejection fraction, researchers found no differences in the significant reduction of the primary outcome of cardiovascular death or heart failure hospitalization over 36 months based on whether patients were diabetic.
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Predicting the Tolerability of Sacubitril/Valsartan in Advanced Heart Failure
An analysis of the sacubitril/valsartan run-in period for chronic, advanced heart failure patients showed 18% could not tolerate the lowest dose, usually because of hypotension or renal dysfunction. Investigators identified six predictors of non-tolerance, which may help clinicians choose the best candidates.
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Provocative Testing with Intracoronary Acetylcholine as Part of Cardiac Catheterization Evaluation
In this systematic review and meta-analysis of invasive coronary provocation testing, intracoronary acetylcholine was found to be a safe procedure, with low rates of major complications.
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Clinical Significance of Mitral Annular Calcification
Researchers found mitral annular calcification to be uncommon, and few experience associated moderate to severe mitral stenosis or regurgitation. However, the latter group recorded a high mortality rate over three years follow-up, which was significantly lower in those who underwent valve interventions, even when corrected for younger age, fewer comorbidities.
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Appropriate Management of Thoracic Aortic Aneurysms
Among patients with arch and descending thoracic aorta aneurysms followed over a mean 20 months, aneurysm-related mortality was predicted by the size and growth rate of the aneurysms, along with age and sex.
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The Darkest Hour: Little PPE, No Vaccine Led to Moral Injury
A fascinating and disturbing study captures the emotions and attitudes of healthcare workers in 2020 when COVID-19 emerged. Personal protective equipment was in short supply, and the first COVID-19 vaccines would not be available until the end of the year. There was a general despairing feeling in this period that there was not “enough” of anything, including reliable information.
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Moral Injury in HCWs at Level of Combat Vets
Moral injury is a fairly well-established syndrome in combat soldiers, but researchers found healthcare workers suffered a comparable level of mental turmoil and ethical conflict during the first two years of the pandemic.
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Dealing with Toxic Employees
Everyone has met him or her — and would prefer not to meet them again. But there they are when you arrive for duty: The toxic co-worker.
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Survey: 87% of Acute Care Sites Short of Nurses
Healthcare delivery is at a critical tipping point due to a nursing shortage crisis that is projected to get worse, and no clear consensus on new labor models to meet the crisis, according to a survey and report by two companies involved in medical education and labor solutions. Even before the pandemic drove workers from the clinical bedside, experts projected 1 million more nurses would be needed by 2030.
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Healthcare Workers Likely Will Be Offered New Vaccine
Healthcare workers likely will be offered a new COVID-19 vaccine the FDA is pushing to roll out for this fall and winter. The FDA Vaccines and Related Biological Products Advisory Committee approved “the inclusion of a SARS-CoV-2 omicron component for COVID-19 booster vaccines in the United States.”