Articles Tagged With:
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Adjunctive Corticosteroids in Patients with Severe Community-Acquired Pneumonia
A double-blind, randomized, controlled trial conducted at 31 French medical centers demonstrated adult patients with severe community-acquired pneumonia who were given hydrocortisone had a lower risk of death by day 28 compared with those who received placebo.
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Shortening the Duration of Tuberculosis Treatment
In patients with rifampin-susceptible tuberculosis, a planned eight-week regimen of bedaquiline plus linezolid together with isoniazid, ethambutol, and pyrazinamide, combined with a careful follow-on strategy, was non-inferior to a standard six-month regimen.
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SER-109 Improves Quality of Life Compared to Placebo in Patients with Recurrent Clostridioides difficile Infection
A secondary analysis of a Phase III clinical trial found SER-109 improved health-related quality of life for patients with recurrent C. difficile infection compared to placebo through eight weeks.
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Challenges in Diagnosing MIS-C
Even though there are clear diagnostic criteria for multisystem inflammatory syndrome in children (MIS-C), the initial diagnosis is not always certain, and there can be overlapping concurrent bacterial, viral, and parasitic infections that also require prompt treatment.
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Outbreak of Botulism Due to Intragastric Botulinum Toxin Injection for Weight Loss
An outbreak of botulism after intragastric injection of botulinum toxin to cause weight loss has, to date, affected at least 87 patients.
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Infectious Disease Alert Updates
Occupational Mpox in Healthcare Workers; Homeless People at Risk for Mpox; PRIORIX Is Interchangeable with MMRII
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Legal Exposure for EDs if On-Call Consultant Refuses to See Patient
There are multiple tactics to secure a consult, even if a specialist is busy. However, if a bad outcome occurs because there was no consult, clinicians should not play the blame game.
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Subcutaneous IVIG for Treatment of Myasthenia Gravis
A Phase II trial comparing subcutaneous (SC) administration of pooled immunoglobulin to intravenous (IV) administration of immunoglobulin in 23 patients with seropositive myasthenia gravis demonstrated a stable course after transition from IV to SC.
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Inclusion Body Myositis: Variability and Clinical Subsets
Inclusion body myositis (IBM) is a progressive myopathy characterized by prominent finger flexor and quadriceps involvement. Black patients with IBM have more prominent proximal weakness, in addition to finger flexion and quadriceps weakness. Female patients have less prominent finger flexion and quadriceps weakness and slower progression, whereas younger patients had a greater delay in diagnosis. There are variability and distinct clinical subsets among IBM patients, which can have implications in terms of timely diagnosis and possibly response to treatments.
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The Neural Pathways of Pain Treatment Response in Small-Fiber Neuropathy
Pain in peripheral neuropathy, referred to as neuropathic pain, is thought to result from overexpression of pain receptors, regeneration of hypersensitive nerve sprouts, and denervation hypersensitivity of neurons in the sensory ganglia. Additionally, activation of the pain pathways appears to induce secondary structural and functional changes in the brain that contribute to pain perception, persistence, and response.