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In this prospective study of older ICU patients (mean age, 67 years), frailty as assessed by a simple scale was present in one-third and was strongly associated with increased risk of adverse events, morbidity, and mortality.
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After caring for patients with Clostridium difficile infection, nearly 25% of health care workers were found to have hand contamination with C. difficile spores.
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This study investigates the role of metabolic dysregulation of the insulin-glucose axis and the risk of obesity-related cancers in the Framingham Heart Study Offspring Cohort over approximately 37 years. The authors found that impaired fasting glucose exposure for a period greater than 10 years increased obesity-related cancer risk.
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A systematic review and meta-analysis of randomized controlled trials of meditation programs demonstrated moderate strength of evidence for mindfulness meditation for improving anxiety, depression, and pain.
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This study reviews a recent example of hepatotoxicity from a dietary supplement and discusses the issues related to retroactively monitoring nutritional supplements for adverse effects.
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In a trial comparing chemotherapy alone to chemotherapy plus bevacizumab in the treatment of patients with platinium-resistant ovarian cancer, the combination resulted in improved response rates and progression-free survival (PFS) and without a high rate of added toxicity. Whether bevacizumab alone would provide comparable improvements was not assessed but remains an important question for future trials.
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Group A streptococcus (GAS) may cause disease both by direct infection, termed suppurative disease, and also by the response of the body to an antecedent infection, termed nonsuppurative disease. An invasive GAS infection is defined as one in which GAS can be isolated from a part of the body that is normally sterile, as would be the case in pneumonia but not in pharyngitis.
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The recent publication of the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and the continuing introduction of new psychoactive drugs create challenges for updated diagnostic and therapeutic choices for primary care patients.
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A growing number of health care workers are coming into their profession with childhood vaccination against hepatitis B virus (HBV).