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As concerns grow over the expense and slow progress of classic randomized clinical trials (RCTs), an intriguing alternative is gaining steam adaptive design, in which trials change at various decision points in response to accumulated data.
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Difficult intubations are usually the result of a difficult airway, sometimes anticipated and sometimes not.
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This study sought to determine whether the coagulo-pathy associated with chronic liver disease specifically the elevated International Normalized Ratio (INR) frequently present in patients with advanced disease is protective against venous thromboembolism (VTE) in hospitalized patients.
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Peterson and colleagues at rush university medical Center carried out an observational study of ICU patients' oral nutritional intake in the 7 days following extubation after mechanical ventilation for acute respiratory failure.
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In this issue: New reports about proton pump inhibitors and the effects of gastric suppression, pioglitazone vs vitamin E for non-alcoholic steatohepatitis, metformin and vitamin B12 deficiency, and FDA Actions.
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Patients with neuromuscular disease who are intubated and subsequently fail multiple spontaneous breathing trials are often relegated to placement of a tracheo-stomy and continuous mechanical ventilation.
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Terragni et al performed this 4-year-long multicenter randomized controlled trial to determine whether early (6-8 days) vs late (13-15 days) tracheotomy would reduce ventilator-associated pneumonia (VAP) incidence.