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The Lynch Syndrome (hereditary non-polyposis colorectal cancer) is a cancer susceptibility syndrome highlighted by early age onset of cancers of the colon and rectum, endometrium, ovary, small bowel, ureter and renal pelvis. It is mediated via autosomal dominant transmission of germ-line mutations in DNA-mismatch repair genes.
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The Osteoporosis Prevention and Arterial Effects of tiboLone (OPAL) study was a 3-year, randomized, double-blind trial in 6 US centers and 5 European centers, treating 866 postmenopausal women with either 2.5 mg tiboLone daily, 0.625/2.5 mg daily of conjugated estrogens/medroxyprogesterone acetate, or placebo.
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Advanced stage endometrial cancer represents a significant therapeutic challenge as it encompasses patients with a diverse spectrum of disease and recurrence risk. Currently, most patients are treated following primary surgical extirpation with a modality either directed at tumor residua or to a high-risk locale of recurrence. Either or both radiation therapy and chemotherapy have been used.
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In the January issue of the American Journal of Obstetrics and Gynecology an article from Japan appeared that will shed new light on the practice of using cerclage in patients with short cervices. Over a 5-year period 16,508 had transvaginal ultrasound evaluations between 20-24 weeks.
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Study: Quality, patient safety improving at a modest pace; CDC issues updated TB prevention guidelines; Health care disparities narrow for many
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Erectile Dysfunction and Subsequent Cardiovascular Disease; Oseltamivir for Influenza A Infection; Dietary Intake of Antioxidants and AMD; High-Dose Acyclovir in Pityriasis Rosea; High-Dose Acyclovir in Pityriasis Rosea; Rimonabant and Weight and Risk Factors in Obese Patients; Watchful Waiting vs Repair of Inguinal Hernia in Minimally Symptomatic Men;
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An adult patient, who had been diagnosed with diabetes at age 11, was admitted for surgery to repair his retina due to injuries related to diabetic retinopathy.