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The most appropriate time to intervene in asymptomatic patients with chronic severe aortic regurgitation is controversial. Since brain natriuretic peptide (BNP) is released by the heart in response to increased wall stress, it has been proposed as a biomarker of the time to intervene in chronic valvular regurgitation patients.
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Anatomic definition of coronary artery lesions by invasive coronary angiography (ICA) or computed tomography coronary angiography (CCTA) has limitations.
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Most patients with ST-elevation myocardial infarction (STEMI) present to hospitals that are not capable of percutaneous coronary intervention (PCI). Rapid transfer to PCI-capable facilities for primary PCI may result in earlier reperfusion of the infarct artery and better clinical outcomes. However, delays in transfer may diminish the mortality benefit achieved with primary PCI in STEMI.
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This basic science paper explores the role of the tumor microenvironment in the development of tumor resistance to chemotherapy. Two distinct fatty acid molecules, endogenously produced by cancer cells in response to platinum-based chemotherapy drugs, were found to confer significant tumor chemoresistance. Remarkably, these two fatty acids also were shown to be present in several commercial fish oil products, and, of potential import to clinicians, the oral administration of small amounts of these fish oils induced tumor resistance to cisplatin in a mouse tumor model.
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In postmenopausal women, constipation is associated with having major risk factors for cardiovascular disease and increased cardiovascular risk.
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This is the second in a three-part series about the design and conduct of clinical research.
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If you're planning to invest in dozens of mountain bikes for sedentary office workers to ride during lunch breaks, you may abandon the idea if most admit they'd never use them because they don't want to get sweaty at work. On the other hand, if a worker tells you she wouldn't dream of using the company gym because it's too dirty, providing antibacterial wipes is an easy, low-cost solution.
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Growing numbers of companies are implementing "no hire" policies for smokers, while others are imposing health premium penalties for workers who smoke. Reasons include higher health care costs, decreased productivity, and higher absenteeism all linked to smoking.