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It has been well recognized that a peak in stroke onset occurs during the early morning hours. This possible circadian periodicity is not well understood, and may in part represent stroke onset earlier during the night that goes unrecognized until the patient arouses.
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In nonvalvular atrial fibrillation patients, rivaroxaban was noninferior to warfarin for the prevention of stroke or systemic embolism. However, an intention-to-treat analysis did not show superiority of rivaroxaban over warfarin.
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For many patients with moderate- severe chronic obstructive pulmonary disease, acute exacerbations (AECOPD) are highly problematic.
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Both urgency and bladder pain can lead to nocturia in patients with interstitial cystitis.
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A kinase inhibitor for late-stage melanoma and its companion diagnostic test have been approved by the FDA.
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The authors conclude that this large observational study suggests ACEI or ARB therapy is associated with an improved survival and a lower risk of cardiovascular events in patients with aortic stenosis.
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Participation in Weight Watchers resulted in a greater weight loss over a year than did clinical intervention in a primary care office.
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Data from this large observational trial with an average follow-up of over 8 years suggest that even 15 minutes a day of moderate-intensity exercise, such as taking a brisk walk, provides significant health benefits in terms of lowered mortality risks and life extension.
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In a case-control study using a biomarker for lignan intake, women with breast cancer who had higher levels of the biomarker post-diagnosis had a reduced risk of mortality over a median follow-up period of 6 years compared to women with low levels of the biomarker.