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Clinical Briefs
Updates on treatment of depression, the prevention and treatment of osteoporosis, and subclinical thyroid dysfunction as it relates to fracture risk.
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Pharmacology Update: Memantine HCl and Donepezil HCl Capsules (Namzaric™)
The addition of memantine to a stable dose of an acetylcholinesterase inhibitor may improve cognitive performance.
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PCSK9: A Major New Advance in Cholesterol-lowering Therapy
When added to statin therapy at the maximum tolerated dose, the PCSK9 inhibitor alirocumab reduced low-density lipoprotein cholesterol levels by 62% and also reduced the rate of occurrence of cardiovascular events.
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Obesity Paradox and Diabetes
In a prospective cohort study of overweight or obese type 2 diabetics, being overweight was associated with a lower mortality risk, but being obese was not.
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Can CPAP Treatment Prevent Dementia?
ABSTRACT & COMMENTARY: Older people with sleep apnea had onset of cognitive decline at an earlier age than those without sleep apnea.
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Liletta: A New LNG-IUS Option
Initial clinical results with a new 52 mg levonorgestrel intrauterine system recently introduced to the market and approved for three years of use are similar to those seen with the existing system.
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Non-medically Indicated Inductions of Labor
A recent study in patients having non-medically indicated inductions of labor has shown that this option is associated with higher cesarean section rate at 38 and 40 weeks, but not, interestingly, at 39 weeks, at which time there was a lower rate of peripartum infections, fewer newborn special care unit admissions, but longer labors. However, these data do not speak for empiric induction of labor at 39 weeks without medical indication.
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Why Aren’t Women Using Contraception?
ABSTRACT & COMMENTARY: This cross-sectional study highlights new risk factors for nonuse of contraception among women at risk for unintended pregnancy.
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Antral Follicle Count Does Not Predict Pregnancy During Unstimulated Donor Insemination Cycles
Early follicular phase antral follicle count as a method of analyzing ovarian reserve is not helpful in predicting subsequent pregnancy in women with normal cycles.
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Progesterone and Indomethacin and PTL
One recent study has questioned the efficacy of the ability of 17 alpha-hydroxyprogesterone caproate to prevent preterm birth, and the other suggests that indomethacin, used to stop preterm labor, may have unwanted neonatal consequences.