Articles Tagged With:
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Ocrelizumab for Multiple Sclerosis
A Phase III trial of ocrelizumab in primary-progressive multiple sclerosis and two Phase III trials of ocrelizumab in relapsing-remitting multiple sclerosis have demonstrated efficacy with treatment.
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New Tools for the Diagnosis of CJD
Cerebrospinal fluid analysis using second-generation, real-time, quaking-induced conversion has a high sensitivity and specificity for the diagnosis of Creutzfeldt-Jakob disease.
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Fatal Infection Resistant to All Antibiotics
Last August a female patient in an acute care hospital in Reno, NV, died of carbapenem-resistant Enterobacteriaceae that was resistant to 26 antibiotics. The pathogen was Klebsiella pneumoniae that was isolated from a wound specimen. Of note, the patient had recently been hospitalized in India, and the specific enzyme conferring pan resistance was first discovered in that country: New Delhi metallo-beta-lactamase.
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MRSA Screening Has Collateral Benefits
Lead author Martin E. Evans, MD, an infectious disease physician at the University of Kentucky in Lexington, reports that infection rates fell 80% percent in non-ICUs, and 81% percent in spinal cord injury units.
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Wanted: The Next Generation of Infection Preventionists
A national survey of 4,078 infection preventionists shows that the field is approaching a demographic cliff, as 41.6% of respondents were age 56 years or older.
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Will SHEA Drop Flu Shot Mandate of HCWs?
“Given the assault on science that we are likely to see over the next four years in the U.S., SHEA must lead by ensuring that all of its recommendations are solidly based in evidence and that expectations for compliance with interventions correlate with the strength of the evidence,” notes Michael Edmond, MD, clinical professor of internal medicine and infectious diseases at the University of Iowa in Iowa City. “Just as we must defend vaccines from false claims of adverse effects, we must also truthfully acknowledge their limitations and shape our policy on science not opinion.”
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Study: Flu Shot Mandates Unsupported by Science
The four trials were conducted in long-term care facilities, but have generally been extrapolated to support flu immunization requirements in acute care and other settings. Among other benefits, the studies generally link reductions in resident mortality to higher staff flu vaccination rates. With healthcare worker vaccination rates lagging in most hospitals, several facilities began mandating immunization several years ago in what has since become a national trend.
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Troponin Highly Prognostic in Decompensated Heart Failure with Preserved Ejection Fraction
SYNOPSIS: Among patients with acute decompensated heart failure and preserved ejection fraction, elevated troponin is associated with worse in-hospital outcomes and long-term survival, independent of other predictors.
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NOACs in Patients Requiring Anticoagulation Post-PCI
SYNOPSIS: The PIONEER study of atrial fibrillation patients post-percutaneous coronary intervention showed that regimens of clopidogrel plus reduced-dose regimens of rivaroxaban demonstrated lower bleeding and similar rates of stroke and adverse cardiac events compared with traditional warfarin triple therapy.
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A New Risk Score for Stroke in Atrial Fibrillation
SYNOPSIS: A new, simpler score for stroke risk prediction in atrial fibrillation patients uses biomarkers to supplant many clinical variables and outperforms the CHA2DS2-VASc score in two large cohorts.