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  • Anaphylaxis: An Underrecognized Killer

    Prompt diagnosis and treatment improve outcomes

  • Atypical Transient Symptoms Require Aggressive Investigation for Cause

    Atypical transient symptoms, such as partial sensory deficit, dysarthria, vertigo and unsteadiness, unusual visual deficits, and diplopia, usually are not classified as transient ischemic attacks, and they frequently are not investigated in the same fashion. However, one-year risk of recurrent major vascular events was not significantly different between patients who had typical TIA symptoms or atypical isolated or non-isolated symptoms. Therefore, these patients should be investigated intensively in a manner similar to patients with classical TIA symptoms.

  • What Is the Risk of Hemorrhage During Pregnancy for a Woman with Brain Arteriovenous Malformation?

    The risk of hemorrhage in a pregnant woman with a brain arteriovenous malformation (AVM) is uncertain and management is controversial.

  • Deep Brain Stimulation May Offer Hope in Treating Post-stroke Pain

    This trial of deep brain stimulation of the ventral striatum/anterior limb of the internal capsule improved several measures of the affective sphere of pain in those suffering from post-stroke pain, despite no significant improvement seen in the pain disability index.

  • Migraine and the Blood-brain Barrier

    During spontaneous attacks of migraine with visual aura, magnetic imaging studies indicate that the blood-brain barrier remains intact and the pons is activated.

  • Omega-3 Polyunsaturated Fatty Acid Supplementation and Cognitive Decline

    In a randomized, placebo-controlled trial of 1,680 participants aged 70 years or older, there was no significant difference in cognitive decline between any of the intervention groups taking omega-3 polyunsaturated fatty acid supplementation and/or multidomain intervention (physical activity, cognitive training, and nutritional advice) compared to the placebo group. However, exploratory post hoc analyses showed some promise for a protective effect with intervention in certain at-risk subgroups.

  • Distinguishing the Neuropathy Associated with MGUS from POEMS

    Nerve conduction and electromyography can help differentiate the neuropathy associated with monoclonal gammopathy of undetermined significance (MGUS) from polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS).

  • Randomized Trial of Cannabidiol for Medically Refractory Seizures in Dravet Syndrome

    In a double-blind study, 120 children and young adults with the Dravet syndrome and medically refractory seizures were assigned randomly to receive either cannabidiol or placebo, as well as their usual antiepileptic drugs/therapies. The primary finding was a significant decrease in convulsive seizure frequency during the 14-week treatment period for patients receiving cannabidiol compared to those receiving placebo.

  • Stroke: Rehabilitation and Recovery

    Rehabilitation is a critical component of stroke treatment, as most stroke survivors are left with significant neurological impairments and other sequelae, such as spasticity and pain. Stroke rehabilitation aims to reverse these impairments to the extent possible, maximize functionality through the use of compensatory approaches, prevent complications, and manage comorbidities. This article reviews the basic principles of rehabilitation, current practices, and evidence supporting various aspects of stroke rehabilitation.

  • Systolic and Diastolic Heart Failure

    Acute decompensated heart failure is a serious condition that presents in the emergency department and the intensive care unit. The causes of heart failure are multifactorial, making it, at times, difficult to diagnose and treat.