A pooled analysis comparing the risk of venous thromboembolism associated with combined oral contraceptives (COC) found significantly decreased venous thromboembolism risk in estradiol valerate-dienogest COCs compared with ethinyl estradiol-levonorgestrel COCs (propensity score-stratified hazard ratio, 0.46; 95% confidence interval, 0.22-0.98).
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