News Brief: Norplant and Vitamin E
News Brief
Norplant and Vitamin E
July 2001; Volume 3; 55
Endometrial bleeding is a common reason for discontinuing use of Norplant (a levonorgestrel subdermal contraceptive implant). A randomized, double-blind, placebo-controlled trial tested 200 mg/d vitamin E or placebo (10 days/month for two months) in 72 Norplant users with bleeding problems. Compared to baseline, the number of days with bleeding decreased significantly in both the treated and placebo groups (from 18.1 ± 1.0 to 7.7 ± 1.4 in the vitamin E group and from 20 ± 1.13 to 12.1 ± 1.3 days in the placebo group). The benefit of vitamin E was seen in both the first and second month. It is not clear, however, that the difference between the treated and placebo group is clinically significant. The study was supported by the World Health Organization and the Department of Education and Culture of the Republic of Indonesia.
Source: Subakir SB, et al. Benefits of vitamin E supplementation to Norplant users—in vitro and in vivo studies. Toxicology 2000;148:173-178.
July 2001; Volume 3; 55
Subscribe Now for Access
You have reached your article limit for the month. We hope you found our articles both enjoyable and insightful. For information on new subscriptions, product trials, alternative billing arrangements or group and site discounts please call 800-688-2421. We look forward to having you as a long-term member of the Relias Media community.