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The International Breast Cancer Intervention Study (IBIS) performed by a collaborative group from the United Kingdom, Australia, New Zealand and some additional European countries initiated a trial in 1992 to determine the role of Tamoxifen in the prevention of breast cancer in women at high risk.

The IBIS-1 Breast Cancer Prevention Trial: Initial Results

The International Breast Cancer Intervention Study (IBIS) performed by a collaborative group from the United Kingdom, Australia, New Zealand and some additional European countries initiated a trial in 1992 to determine the role of Tamoxifen in the prevention of breast cancer in women at high risk.