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Carried out in four ICUs in the Netherlands, this study evaluated the effects of a serum lactate-guided resuscitation protocol during initial management of critically ill patients with elevated lactate levels, as compared to standard management not guided by serial lactate measurements.

Abstract & Commentary: Early Aggressive Therapy to Reduce Serum Lactate Levels Improves Outcomes in Critically Ill Patients

Carried out in four ICUs in the Netherlands, this study evaluated the effects of a serum lactate-guided resuscitation protocol during initial management of critically ill patients with elevated lactate levels, as compared to standard management not guided by serial lactate measurements.