Women Have a Higher Risk for Rupture of Intracranial Aneurysms than Men, Not Explained by Aneurysm Characteristics

It has been noted by clinicians that women have a higher risk of rupture of intracranial aneurysms than men, but in epidemiological studies this was not found to be an independent risk factor. These investigators undertook a review of several large, prospective studies and performed a meta-analysis to assess the characteristics that might be different between men and women to explain these observations.