Vaginal Misoprostol vs. Prostaglandin E2 Pessary for Induction of Labor at Term

In this randomized, noninferiority, clinical trial of pregnant women who underwent induction of labor with misoprostol compared to dinoprostone, the rate of vaginal delivery within 24 hours was higher in the misoprostol group. Maternal satisfaction, assessed by a visual analog scale, also was higher. Although the noninferiority of dinoprostone to misoprostol could not be demonstrated, the clinical risk-to-benefit ratio justifies the use of both drugs.