Falls in the Elderly
AUTHORS
Mara O’Sullivan, MD, Department of Emergency Medicine, Wright State University Boonshoft School
of Medicine, Kettering, OH
Andrea L. Kaelin, MD, FAAEM, Assistant Professor, Emergency Medicine, Wright State University Boonshoft School of Medicine, Kettering, OH
Ashley Brent, Medical Student, Wright State University Boonshoft School of Medicine, Kettering, OH
PEER REVIEWER
Ademola Adewale, MD, Director of Research and Simulation, AdventHealth, Orlando, FL
With the population aging worldwide, emergency department (ED) visits related to falls in people older than 65 years of age are on the rise.1,2 Falls cause significant morbidity and mortality among elderly patients compared to younger patients.3-5 When treating a patient who has fallen, the emergency medicine physician should identify traumatic injuries, evaluate for medical pathology contributing to the fall, as well as manage the patient.
The elderly are a vulnerable population with communication barriers that may include regional language barriers, speech or hearing deficits, history by proxy from a living facility or caregivers, and dementia. Numerous comorbidities convey a higher risk for serious pathology associated with age. Emergency medicine clinicians need to have a high index of suspicion for serious pathology, even after a low-mechanism trauma.
Fatal and nonfatal falls in patients older than 65 years of age cost an estimated $49.5 billion in 2015, a 32% increase in healthcare dollar expenditures compared to the previous year.6
Definition of the Problem
This article focuses on ground level falls in adults older than 65 years of age who present to the ED. The elderly population is the fastest growing subset in the United States, and 10-15% of ED presentations are falls in geriatric patients.7 More than one in four elderly people fall annually,1 and there is an increasing mortality rate and admission rate in U.S. older adults who fall.7
Traumatic injuries are the result of the mechanical component of a fall, such as intracerebral hemorrhage and long bone fractures. Medical issues (i.e., seizure, stroke, or hypoglycemia) may be contributive, causing fall conditions. Medical conditions also complicate subsequent medical management, such as anticoagulation therapies, medical devices that are not compatible with magnetic resonance imaging (MRI), or underlying chronic obstructive pulmonary disease (COPD) in the management of rib fractures. Each workup and evaluation should be tailored to the patient’s specific presentation and comorbidities. A thorough history should include emergency medical services (EMS), family, or facility history of the patient at baseline and the situation surrounding the incident. All patients should receive a comprehensive physical examination to avoid delayed medical or traumatic diagnoses.
Etiology and Epidemiology
Elderly patients have greater injury severity scores than younger patients with comparable mechanisms of injury. Higher injury severity scores are largely due to association with the comorbid medical conditions of COPD, ischemic heart disease, diabetes, cirrhosis, and coagulopathies.8 Almost 95% of all hip fractures are caused by falls.9
Mortality from falls, especially in those older than 75 years of age, continues to trend upward.8,10 In 2016, 116.4 per 100,000 men and 105.9 per 100,000 women died with falls as the underlying cause of death.10 Predictors of mortality, independent of age, for the elderly with an injury severity score (ISS) of > 16 include Glasgow Coma Scale (GCS) score ≤ 8, international normalized ratio (INR) > 1.4, a base excess ≥ -6, and acidosis.11 Geriatric patients experience additional complications that lead to age-related higher mortality during post-trauma hospitalization, such as delirium, pneumonia, and respiratory failure.4,11 Two-thirds of all patients who fall sustain recurrent falls within the next 12 months.7,9
Pathophysiology
Normal physiologic changes in older adults include decreased cardiac output and maximum heart rate, decreased muscular strength and flexibility, decreased pulmonary reserve and oxygen exchange capacity, and decreased bone density.4 These changes are exacerbated by muscle atrophy, deconditioning, gait instability, balance impairment, frailty, sedentary lifestyles, visual impairment, polypharmacy, and numerous medical conditions that place the geriatric patient at an even greater risk for falls and injury. (See Table 1.) Older adults have higher rates of arthritic disease and are predisposed for a higher incidence of spinal injuries than similar mechanism counterparts.12 Cerebral atrophy, vascular frailty, hypertension, ubiquitous atherosclerosis, and reduced cerebral autoregulation all increase the risk of intracranial pathology, including subdural hemorrhage and hypoxic brain injury, from a fall.13
Table 1. Physiologic Considerations in Elderly Fall Patients |
||
|
Organ System |
Elderly Physiology |
Consequence |
|
Neurologic |
Decreased visual acuity and depth perception Cognitive decline Cerebral atrophy Balance and gait disturbance |
Unable to identify obstacles Unreliable history Tearing of intracranial bridging veins Unable to react to obstacles |
|
Musculoskeletal |
Frailty/deconditioning Osteopenia Anticoagulation |
Difficulty regaining post-trauma level of function Increased incidence of fractures Bruising, compartment syndrome |
|
Dermal |
Decreased collagen and elasticity |
Skin tearing, decreased wound healing |
|
Hematologic |
Anticoagulation |
Hemorrhage |
|
Cardiovascular |
Decreased cardiac output Atherosclerosis |
Decreased ability to compensate for shock or arrhythmia Thrombosis or emboli, decreased peripheral perfusion |
|
Pulmonary |
Decreased perfusion capacity Decreased ciliary activity |
Higher sensitivity to pulmonary contusion Increased incidence pneumonia |
|
Hepatorenal |
Altered medication metabolism and clearance |
Increased medication adverse effects |
Since physiological and chronological age are highly variable in this population, fall patients may not have a generalizable pattern of injury. Not all elders are frail; however, age generally confers frailty in addition to increased comorbidities.4 As age increases, major traumatic injuries may be present with lower mechanisms of injury, such as a fall from the bed to the floor. For example, an octogenarian with a ground level fall is more likely to sustain cervical spine, upper extremity, pelvic, and rib fractures than a younger elder. Worsening injury severities portend an increased mortality as well.14
Presentation and Initial Evaluation
After a higher mechanism fall, such as a fall from a distance of greater than 20 feet, severe head injury, low GCS, or obvious deformity of more than two long bones should involve coordination across trauma surgery and critical care specialties, sometimes called “trauma alert.” Although it requires further study, an increased trauma alert level for patients older than 70 years has been shown to decrease mortality and hospital length of stay.15 Consider age as a risk factor in itself for increased mortality for similar traumas during triage because the three greatest risk factors for undertriage include being female, falls, and age.10
Diagnostic studies need to evaluate for a broad differential diagnosis in a cost-effective manner and should be guided by the patient’s history and physical exam. Ask about loss of consciousness and duration, witnesses to the fall, seizure-like activity including tongue biting and loss of bowel or bladder control, alcohol and substance use, comorbid conditions, and medication use. Include questions about provocation, prodrome, and prior history of falling.16 Interview EMS and family members for collateral details. Differentiation between seizure and syncope requires a witnessed account; syncopal falls commonly exhibit brief, unsustained seizure-like activity.16 Prehospital EMS providers can offer critical information on the conditions and environment that elaborate on the presentation, scene construct, and initial vital signs for patients “found down.” Additionally, chart reviews can divulge the patient’s comorbidities, medications, and baseline neurologic status. Finally, do not overlook the review of systems, which adds clues in the search for the cause of a fall.
Physiologic Parameters
When compared to the baseline health of the patient, vital signs predict injury severity and may prompt early recognition of pathology. Be wary of a patient with chronic hypertension and a systolic blood pressure (SBP) of 90 mmHg; reductions in SBP of 30 mmHg below baseline may be hypoperfusing vital organs.4 Review medication lists for antihypertensives, cardiac rate or rhythm control agents, and anticoagulation medications to properly contextualize the vital signs of the elderly patient in the setting of a trauma resuscitation. Elderly patients are at an increased risk of thermal injuries due to mobility restrictions, physiology, and medications. Work with the nursing team to obtain a core temperature early, and prevent hypothermia with external warming measures. For patients who present with core temperature < 35°C or > 40°C consider endocrine, infectious, or toxicologic pathology and environmental injury in the differential. In the unstable patient, initiate multiple large bore intravascular access, with intraosseous access as an alternative if vascular access cannot be achieved. Place the patient on the cardiac monitor and continuous pulse oximetry, addressing hypoxia with supplemental oxygen. Begin resuscitation to achieve a mean arterial pressure (MAP) goal of > 65 mmHg.17
Traumatic Evaluation and Management
Advanced Trauma Life Support
In the elderly population, ground level falls are the most common mechanisms of trauma.5,14 Follow the advanced trauma life support (ATLS) protocol; prioritize the airway, breathing, and circulation in the clinically unstable or unconscious patient.18 Include the extended focused assessment with sonography in trauma (EFAST) in the primary survey to assess for the presence of intra-abdominal free fluid, pericardial effusion, and appropriate bilateral lung sliding. Intervene early and reassess quickly since the elderly have less adept physiologic compensation to hypovolemia and shock. Protect the patient from the trauma “triad of death”: hypothermia, acidosis, and coagulopathy,19 including iatrogenic causes during the resuscitation. The ATLS-10, the 2018 update, places emphasis on vital sign trends and base excess to assess hemorrhage class and transfusion needs, instead of using static values.8
Balance the risk of airway compromise with high mortality of elderly intubated patients (20% of those > 80 years of age) when determining if intubation is needed. Hypoxia and hypotension increase complications and mortality for this population during airway management, so adequately plan, preoxygenate, optimize resuscitation, and prepare to manage hemodynamic instability.20 Special procedural considerations for intubation in this population include dentures, limited neck extension, and decreased temporomandibular joint mobility20; favorable positioning and video laryngoscopy can assist to overcome these challenges. Ensure cervical spine immobility when assessing the airway, if indicated. Regardless of intubation status, assess for symmetrical chest rise with auscultation of breath sounds, and look for hemorrhage while ensuring equal and strong pulses in all extremities.18 Ensure judicious use of small volume boluses of intravenous crystalloid fluid for hypotension since it potentially can worsen coagulopathy and acidosis; initiate blood product resuscitation early for evidence of hemorrhage.18 When evaluating disability, a decreased GCS may misrepresent neurologic injury if the patient’s baseline is not 15.8 Lastly, remove the patient from the backboard as soon as possible because older individuals have increased risk of skin breakdown in a shorter period of time.4 Complete a secondary survey with a thorough physical exam as well as ancillary imaging of musculoskeletal injury and computed tomography (CT) as indicated.18 Forgo advanced imaging if the patient requires transfer unless it will change management, since a delay in transfer to a higher level of care can be detrimental.8
Pain Management
Appropriately treat severe pain since uncontrolled pain increases the incidence of delirium.21 Achieve pain control through a combination of non-opiate medications with cautiously reduced doses of opiates. Geriatric patients have increased sensitivity and increased adverse effects of opiates with hypotension, respiratory depression, and delirium.21,22 Acetaminophen 1,000 mg intravenous (IV) every six hours is a safe option for pain control in the absence of liver failure. If possible, avoid nonsteroidal anti-inflammatory drugs (NSAIDs) because of the potential for medication interactions, renal impairment, and gastric mucosal damage.21 The intubated patient needs to have appropriate sedation with a combination of fentanyl (25-200 mcg/h), propofol (5 mcg/kg/min up to 4 mg/kg/h), midazolam, and/or dexmedetomidine (0.2-0.7 mcg/kg/h) to achieve pain control and the Richmond Agitation-Sedation Scale target.17
Intracranial Injury
A primary consideration in the evaluation of geriatric falls is traumatic brain injury (TBI). Mortality is directly related to increased age and low GCS.23 The differential for elderly traumatic brain injury should encompass cerebral contusions, traumatic subarachnoid hemorrhage, subdural and epidural hemorrhage, skull fracture, facial fractures, and diffuse axonal injury. The risk of injury incurred with anticoagulation use and a low level fall still is unknown,4 but warfarin specifically increases the likelihood of mortality.23 A noncontrast CT scan of the head is indicated in the evaluation of geriatric head injury, since this population experiences increased consequences of similar bleeds than younger patients. Elderly patients may exhibit fewer or later clinical signs of increased intracranial pressure (ICP). A normal GCS does not prove the absence of clinically significant intracranial injury.13 Use CT to image patients with signs of skull fracture, post-traumatic seizure, focal neurologic findings, and reduced post-traumatic GCS. Subdural hematoma (SDH) is the most common type of hemorrhage.13 SDH can present as deteriorating mental status over several hours, but an estimated 20-30% can be caused by arterial bleeding and may present with coma.17 Head CT sensitivity for SDH is close to 100%.17 Also consider a subarachnoid hemorrhage (SAH) as a potential cause of a fall in addition to a sequela of head injury. Detection of SAH with CT exhibits a sensitivity of greater than 99.0% and a specificity 99.9% if it is within six hours of headache onset. For those with symptoms for a longer duration, obtain a CT angiogram or lumbar puncture.24 Dual energy CT is 96% sensitive and 99% specific for intraparenchymal hemorrhage (IPH).25
Declining mental status, pupillary asymmetry, and extensor posturing are signs of cerebral herniation. Rapidly address these findings with measures to lower ICP: Elevate the head of the bed, ensure that a cervical collar does not occlude venous drainage, and cautiously use hyperventilation for brief periods of time to a PaCO2 target of 30 mmHg.13,17 Hyperosmolar therapy can be 3% hypertonic saline or mannitol, at 1-1.5 g/kg boluses.17 In patients with traumatic brain injury, target SBP > 100 mmHg in those 50 to 60 years of age, and > 110 mmHg in those older than 70 years of age. Steroids, therapeutic hypothermia, and hyperventilation within the first 24 hours are not recommended.8,17 Tranexamic acid (TXA) has demonstrated a potential benefit without harm for patients with GCS > 9 for all severity levels of TBI. Administer 1 g TXA slow IV push within the initial three hours of injury, followed by 1 g IV over eight hours.26 Initiate seizure prophylaxis with levetiracetam 500 mg to 1,000 mg orally or IV or phenytoin/fosphenytoin.13,17
Hematologic Considerations
Consider anticoagulation reversal in patients with life-threatening hemorrhage, but especially those with hemodynamic instability or hemorrhage into enclosed spaces. Reversal of anticoagulation and surgical intervention for hemorrhagic complications of head injury are individualized decisions based on the patient’s indication for anticoagulation and risk of continued bleeding weighed against the risk of thrombogenesis.27 Agents for direct oral anticoagulant (DOAC) reversal include idarucizumab, given in a single 5 g IV dose to reverse dabigatran, and andexanet alfa for reversal of the factor Xa inhibitors apixaban and rivaroxaban.27 Ciraparantag is under development for a universal factor for the reversal of Xa and direct thrombin inhibitors.13,27 In those with intracranial hemorrhage (ICH), reverse warfarin with 25 U/kg to 50 U/kg of 4-factor prothrombin complex concentrate (4FPCC or Kcentra) and vitamin K 10 mg IV push,17 or fresh frozen plasma (FFP) if 4FPCC is not available, since 4FPCC has been shown to be noninferior to FFP.23 (See Table 2.)
Table 2. Anticoagulation Reversal |
||
|
Anticoagulant |
Treatment |
Dose |
|
Aspirin |
Desmopressin |
0.4 mcg/kg |
|
Vitamin K antagonist: Warfarin |
Vitamin K AND 4-factor prothrombin complex concentrate (4FPCC) OR Fresh frozen plasma (FFP) |
10 mg IV 25-50 U/kg IV 12-15 mL/kg IV |
|
Direct thrombin inhibitor: Dabigatran |
Idarucizumab |
5 g IV |
|
Factor Xa inhibitors: Apixaban, rivaroxaban |
Andexanet alfa |
Low dose: 400 mg IV High dose: 800 mg IV |
|
Enoxaparin |
Protamine sulfate |
1 mg IV |
|
Direct thrombin inhibitors Factor Xa inhibitors |
Ciraparantag* |
100-300 mg IV |
|
* In development |
||
There is no reversal for antiplatelet agents that has shown improvement for ICH outcomes.13 Give 0.4 mcg/kg of desmopressin IV in those with ICH on antiplatelet medications, such as aspirin.17 Transfusion of platelets is recommended only to maintain platelets > 75 × 109/L in the preoperative setting; trending platelet function testing to guide platelet transfusion is not recommended.17 Consult neurosurgery or expeditiously transfer a patient to a facility with neurosurgical capabilities if there is evidence of increased ICP, declining GCS, focal neurologic deficits, or CT evidence of > 5 mm midline shift, SDH with > 10 mm clot thickness, or > 30 cm epidural hematoma volume.13
Spinal Cord Injury
Ground level falls are the leading cause of spinal cord injury in the elderly,14,28 the majority of which occur at C1-C4.28,29 Geriatric fall patients are twice as likely to have C-spine injuries when compared to younger trauma patients.4 Cervical spine injuries may present with minimal or no neck pain. A diminished level of alertness, distracting injuries, or obvious signs of trauma to the head or neck should prompt clinical suspicion of a C-spine injury.30 Restrict cervical spinal motion until injury is ruled out and complete a thorough neurologic exam, including a cranial nerve and sensory exam. Any neurologic deficits warrant urgent subspecialty consultation.12 The National Emergency X-Radiography Utilization Study (NEXUS) criteria are useful for evaluating use of imaging for low-risk cervical spinal fracture, with 99.6% sensitivity for identification of C-spine injury.30 However, it is recommended that a conservative approach is taken with a low threshold for imaging geriatric patients.31 Alternatively, the Canadian C-Spine rule automatically designates adults > 65 years of age as high risk and recommends radiographic imaging.12 CT is the gold standard to identify vertebral fracture or dislocation, with a sensitivity of 98%.12 Plain film X-ray demonstrates a sensitivity of 52% for identification of cervical spine fractures and may be considered if CT is unavailable.12,28 If one spinal fracture is found, CT the entire spinal column because 10-40% of patients will have multiple spinal fractures.4,12,28 Obtain MRI for clinical concern of ligamentous, soft tissue, or spinal cord injury, and magnetic resonance angiography (MRA) for concern for vascular injury.12 If spinal cord injury is found, avoid movement that could worsen the injury and optimize tissue perfusion with a MAP goal of 85-90 mmHg, thereby maximizing oxygen delivery.28
Skeletal Injury
The most common injuries sustained in falls include head and hip injuries.7 A history of osteoporosis, chronic kidney disease, or chronic steroid use put the patient at an increased risk for fracture. In addition to a complete evaluation of the extremities and immediate reduction of fractures with neurovascular compromise, palpate the chest wall for tenderness, crepitus, or deformity.8 CT imaging of the chest can show rib fractures as well as underlying lung injury, with a sensitivity and specificity for fractures of 95.5% and 99.9%, respectively,31 compared to a poor sensitivity of chest X-ray alone.32 Point-of-care ultrasound identifies rib fractures as well as pneumothorax and facilitates intervention with nerve blocks, but definitive imaging still may be needed to further delineate management.31 Consult general surgery or trauma surgery if the patient has bicornuate rib fractures or flail chest, since the patient may be a candidate for rib plating. Best in-hospital practices for patients older than 45 years of age with more than two rib fractures include aggressive pain control, pulmonary toilet, and prophylactic noninvasive ventilation (NIV) in attempts to reduce intubation and ICU admission during hospitalization.33 For ED management, attempt pain control and NIV before immediate intubation in appropriate candidates who present with respiratory distress secondary to rib fractures. Ultrasound-guided serratus plane block performed by the emergency physician also can bolster pain control. In addition to cardiac monitoring, intralipid rescue should be at the bedside for all plane and nerve blocks with potential for toxicity. Use a long 22 gauge needle to place 20-40 mL of anesthetic, typically 0.25% bupivacaine or 0.5% ropivacaine diluted in a larger volume, between the external intercostal ribs and serratus anterior muscle centered along the fractured ribs.34 For geriatric patients or those with renal or liver disease, use 20% less anesthetic.34 The anesthetic bathes the lateral cutaneous branches of the intercostal nerves and then the intercostal nerves to achieve a multi-level block. Direct visualization with ultrasonography reduces the risk of pleural disruption during fascial layer infiltration.35
Isolated non-displaced rib fractures without underlying pulmonary pathology may be considered for discharge with appropriate pain control and return precautions. Otherwise, have a low threshold to hospitalize an older adult with rib fractures for pain management and observation.4 Risk factors for the development of pneumonia in these patients include more numerary fractures, male gender, alcohol use, and higher volumes of initial IV fluids.24
Falls are a significant mechanism for femur fractures in the elderly, most commonly femoral neck and intertrochanteric fractures. Physical exam findings may include leg shortening, external rotation, severe pain to hip manipulation, and the inability to bear weight. Patients may complain of groin pain or knee pain, since these are common sites of referred pain. Complete an evaluation of the femoral nerves with motor and sensory testing. X-rays are 90-98% sensitive for hip fractures, but occult fractures are best diagnosed by MRI if X-ray is nondiagnostic and pain continues. Evaluate pelvic X-rays for both Shenton line and neck-shaft angle within 120-130 degrees. (See Figure 1.)
Figure 1. Left Intertrochanteric Fracture With Shenton Line Demonstrated on the Right Side |
 |
|
Image used with permission from Catherine Marco, MD, Wright State University Emergency Medicine |
Hemorrhage can be significant with intertrochanteric and subtrochanteric fractures; have a low threshold for blood product resuscitation. The most common complications during hospitalization after a hip fracture include venous thromboembolism and pulmonary infection, but femoral neck fractures can lead to avascular necrosis due to a risk for disruption of the medial and lateral femoral circumflex arteries.36 Consult anesthesia and orthopedic specialists because the best management is multidisciplinary with early surgical correction. Optimize the patient for surgery, including management of electrolyte imbalances and comorbid conditions.37 Fascia iliaca block has been shown to improve patient outcomes with fewer side effects than opiates.22
Other fractures also are sustained in falls. The incidence of ankle, clavicle, hand, and humerus fractures continues to increase, especially in the elderly female population.38 Examine these regions well and, as with all fractures, verify distal neurovascular function and reassess after every patient transfer, repositioning, or splinting procedure.
Medical Evaluation and Management
After the initial trauma evaluation, stabilization, and appropriate specialty consultation, conduct a thorough medical investigation for the causes of falls in the elderly tailored to the patient’s history of present illness and comorbidities. Obtain a point-of-care glucose level.39 The electrocardiogram (ECG) can provide a wealth of information, such as electrolyte abnormalities and toxicologic patterns. Look for ischemia, dysrhythmia, interval abnormalities such as long QT or short PR, hypertrophic cardiomyopathy, Brugada syndrome, arrhythmogenic right ventricular cardiomyopathy, or atrial septal defect.16,40 Further diagnostic testing is presentation driven.41
Syncope
Older adults have an increased incidence of syncope starting at age 70 years.42 Consider syncope in unwitnessed falls, facial trauma, or falls in cognitively impaired patients who cannot accurately recall the events.42 The most clinically concerning causes of syncope are cardiogenic and neurologic,43 while the most common causes of syncope are orthostatic or postprandial hypotension, cardiogenic, vasovagal, and neurologic.42 Cardiac causes of syncope have a high mortality rate, about 10% in six months,43 and underlying cardiac pathology increases this risk.42 (See Table 3.)
The most important initial components in the evaluation of syncope include history, physical exam, and ECG. Consider structural abnormalities such as myocardial hypertrophy or ischemia, pulmonary embolism (PE) or pulmonary hypertension, and valvular pathology, especially aortic stenosis. Elderly patients have less physiologic reserve to maintain cerebral perfusion in the event of decreased cardiac output due to dysrhythmias. Treat ongoing dysrhythmias according to the advanced cardiac life support (ACLS) protocol. Patients with conduction abnormalities, such as bundle branch blocks and fascicular blocks, even if chronic, carry a higher mortality than patients without ECG abnormalities.43 Obstructive PE in patients with dyspnea, tachypnea, or chest pain, especially in those with a history of venous embolism or malignancy, is best investigated with CT angiogram of the chest, with a sensitivity of 92.9% and a specificity 85.7%, compared to a V/Q scan, which has a sensitivity of 57.1% and specificity of 47.8%.41,44 Carotid massage to diagnose carotid sinus syndrome, which is a less common cause of elderly syncope, can be a high-risk maneuver without a high diagnostic yield; it is not generally performed.42,45
Anemia may cause a lightheaded sensation, shortness of breath, or generalized weakness. Evaluate for a gastrointestinal (GI) bleed with a fecal occult blood test in patients with a history of previous GI bleeding or melena, frequent or routine NSAID use, abdominal pain, anticoagulation medication use, or anemia on complete blood count.39
Monitor continuous telemetry and oxygen saturation, with bilateral upper extremity blood pressures to evaluate for aortic dissection or subclavian steal. Consider subclavian steal when syncope, upper extremity fatigue, or vestibulobasilar symptoms are reported together.41 Abdominal aortic aneurysm is more common in elderly men who have a smoking history, and carotid or vertebral dissection can be an atypical presentation of stroke-like symptoms.41 Psychiatric causes of syncope are diagnoses of exclusion. Evaluate life-threatening causes first, and hesitate to make these diagnoses in the ED.43
Within the emergency medicine community, some controversy stems from the debate about disposition for patients with syncope. Up to 50% of patients may not have a specific delineation of syncopal pattern in the ED16; of the remaining patients who are diagnosed during hospitalization, 80% of the time the culprit pattern is diagnosed in the ED.40 Stratify patients into low, medium, and high risk categories and ensure a safe disposition for each.39 Admit high-risk patients with significant cardiac risk factors, including those with a history of structural abnormalities, syncope at rest, exertional syncope, chest discomfort, palpitations, or ECG changes.16,39 For those without definitive risk stratification, several rules can be applied. The San Francisco Syncope Rule is the most studied prediction rule for syncopal outcomes, although validation studies remain inconsistent,46 and it should augment clinical decision making. Serious adverse events occur for patients with a history of congestive heart failure, hematocrit < 30%, shortness of breath, SBP < 90 mmHg, or ECG abnormalities. Lower-risk features that may support outpatient management in lieu of hospitalization include patients with a long history of similar syncopal events and those with prodromal symptoms typical of reflex syncope: syncope after prolonged standing in warm environments, postprandial syncope, or syncope triggered by cough, urination, defecation, or positional changes.16,39
Alternatively, the Canadian Syncope Rule aims to assess and predict 30-day mortality in patients of all ages with syncope.47 If all factors are negative in the patient who does not have a diagnosed cause of syncope, less than 2% of patients followed in the study sustained a serious outcome.46
Admit patients with a score of 1 or higher on the Canadian Syncope Rule.47 Intermediate-risk patients should be monitored on ED telemetry for at least three hours. Admit patients for further workup in the event of a pause greater than three seconds, ventricular tachycardia, high-grade AV block, or bradycardia.39 Counsel patients to avoid high-risk activities, such as driving, until cleared at a follow-up reassessment. For a list of syncope causes discussed, see Table 3.
Table 3. Selected Causes of Syncope |
|||||
|
Origin |
Pathophysiology |
Potential Signs/Symptoms |
Differential Diagnosis |
Workup Indicated |
Further Management |
|
Cardiac |
Ischemia |
Chest pain, SOB, nausea, tachypnea, dyspnea on exertion |
NSTEMI, STEMI, ACS |
ECG, cardiac enzymes, telemetry |
ASA, nitroglycerin, cardiology consult |
|
Cardiomyopathy |
Murmur, multiple episodes syncope |
HCM, ARVC, aortic stenosis |
ECG, Echocardiogram |
Cardiology consult |
|
|
Obstructive |
Dyspnea, SOB, hypoxia, tachycardia, Hx DVT/PE |
PE, pulmonary HTN |
CXR, CTA chest, D dimer, LE US, echocardiogram |
Anticoagulation vs. thrombolytics, cardiology consult |
|
|
Neurologic |
Ischemia |
Focal neurologic deficits, Hx HTN, HLD, atherosclerosis |
TIA, posterior circulation stroke |
CT head without contrast, MRI/MRA |
Neurology consult |
|
Hemorrhagic |
Sudden onset headache, family Hx, personal Hx aneurysm |
SAH, SDH |
CT head, CTA head |
Neurosurgery consult |
|
|
Vascular |
Atherosclerosis |
Abdominal pain, back pain, chest pain, neurologic deficits, unequal pulses or BP, Hx HTN |
Aortic dissection |
CTA chest/abdomen/pelvis abdominal US, cardiac US |
HR control, BP control, investigate for tamponade/MI, vascular surgery consult |
|
Asymptomatic, abdominal pain, flank/back pain, Hx smoking, male |
AAA, mesenteric ischemia |
CTA abdomen/pelvis, abdominal US, lactate |
Blood product resuscitation, vascular surgery consult |
||
|
Vertebrobasilar symptoms Arm fatigue, asymptomatic |
Subclavian steal |
CT chest/upper extremities with contrast |
Vascular surgery consult |
||
|
Infectious |
Inflammatory |
Fever, respiratory or urinary symptoms, abnormal vitals, Hx immunocompromised |
Sepsis, septic shock |
Blood cultures, urine culture, CXR, CBC, lactate |
Antibiotics, IVF, antipyretics |
|
Multiple |
Multivariable |
Dizziness, nausea, diaphoresis, blurred vision, Hx change in position |
Orthostatic hypotension, postprandial or micturition hypotension, GI bleed |
Orthostatic vitals, CBC, INR |
Volume resuscitation |
|
Pharmacological |
New medication or dosage, antiarrhythmic, antihypertensive, QT prolonging medication |
Polypharmacy, medication adverse effect |
Thorough medication review, discuss with PCP |
Variable, possible dosage decrease or medication adjustment |
|
|
SOB = shortness of breath; NSTEMI = non-ST elevation myocardial infarction; STEMI = ST elevation myocardial infarction; ACS = acute coronary syndrome; ECG = electrocardiogram; ASA = aspirin; HCM = hypertrophic cardiomyopathy; ARVC = arrhythmogenic right ventricular cardiomyopathy; Hx = history; DVT = deep vein thrombosis; PE = pulmonary embolism; HTN = hypertension; CXR = chest X-ray; CTA = computed tomography angiography; LE = lower extremity; US = ultrasound; HLD = hyperlipidemia; TIA = transient ischemic attack; MRI = magnetic resonance imaging; MRA = magnetic resonance angiography; SAH = subarachnoid hemorrhage; SDH = subdural hemorrhage; BP = blood pressure; MI = myocardial infarction; HR = heart rate; AAA = abdominal aortic aneurysm; UE = upper extremity; CBC = complete blood count; IVF = intravenous fluids; GI = gastrointestinal; INR = international normalized ratio; PCP = primary care physician |
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Iatrogenic
Patients taking multiple medications should have a review for interactions.39 Anticoagulation, even with clopidogrel, may increase the length of stay in the hospital.48 There is growing evidence that anticoagulation may present less of a risk factor than previously thought for the development of ICH23,49; however, a conservative approach with a low threshold for imaging may prevent significant morbidity for patients on anticoagulation. Beta-blocker and/or calcium channel blocker use may blunt tachycardic response and decrease recognition of clinical instability.4 Medications with arrhythmogenic, QT alteration, or antihypertensive properties should be taken into consideration as a potential cause of syncope.39,43 Include over-the-counter medications and supplements during the review of medications for polypharmacy, defined as five or more medications.42,50 The association between polypharmacy, increased gait disturbance, and prevalence of falls is well established, even when corrected for age, comorbidities, and gender. It also is important to consider that each medication added to an older adult with polypharmacy increases the person’s likelihood of fall.50
Neurologic
Differentiate syncopal falls, which exhibit rapid onset, short duration, and complete resolution without medical intervention, from falls secondary to neurologic pathology. Fall risk is greater for patients with chronic neurologic disorders, such as stroke or dementia; combined disorders convey even greater risk than each disorder alone.51 Screen for stroke mimics by asking about a history of depression or psychiatric illness, epilepsy, migraine, and comorbidities, such as hypertension, diabetes, and atrial fibrillation.52 There is no validated scoring tool to rule out stroke mimics in ED patients.52
Focal neurologic deficits or an elevated National Institutes of Health Stroke Scale (NIHSS) score warrant immediate neurologic specialty consultation, with particular urgency if the symptoms onset within the window for tissue plasminogen activator (tPA) treatment. Optimize blood pressure to SBP < 180 mmHg and diastolic < 110 mmHg in candidates for tPA.53 Trauma is not an absolute contraindication to tPA, but it requires a clear discussion and shared clinical decision making with the patient who may be at increased risk for subsequent bleeding. Review home medication lists with pharmacy for interactions to tPA. The American Academy of Emergency Medicine clinical practice guidelines have not found any evidence to reduce ambiguity for emergency medicine physicians regarding the use of tPA in patients older than 80 years of age or for time windows > 4.5 hours. However, evidence exists for improved morbidity and mortality with admission to a specified stroke unit.54 Emergent neurosurgical interventions with thrombectomy use eligibility criteria and especially seek to include internal carotid artery/middle cerebral artery-sphenoidal segment of MCA (ICA/MCA-M1) occlusion of less than six hours duration, with an NIHSS score ≥ 6 and large vessel occlusions in anterior circulation.55 The NIHSS has decreased detection for posterior circulation ischemia and, similarly, a noncontrast head CT only has a sensitivity in up to 49% of cases for cerebellar pathologies.56,57 Consider posterior stroke in the fall patient with acute onset dizziness with persistent symptoms, altered mental status, dysarthria, neck pain, nausea and/or vomiting, and weakness.58 The head-impulse, nystagmus, test of skew (HINTS) exam is 96-100% sensitive for posterior stroke. Apply it to patients with persistent dizziness without C-spine pathology.58
Transient ischemic attack (TIA) also mimics stroke and may precipitate falls; it is defined as tissue ischemia without evidence of infarct. The American College of Emergency Physicians (ACEP) clinical policy no longer recommends the ABCD2 score as a sole risk-assessment for a patient’s likelihood to have short-term strokes after a TIA. MRA and cervical vascular imaging, including carotid ultrasound, are useful to predict short-term strokes in patients with suspected TIA. Rapid diagnostic protocols to assess 30-day stroke risk for ED patients may decrease cost and length of stay, and can be performed if high-risk features are absent: abnormal head CT, suspected embolic source, known carotid stenosis, history of large stroke, or crescendo TIA.59
A fall with seizure-like activity should raise suspicion for severe electrolyte abnormalities such as hyponatremia or hypoglycemia, or intracranial pathology such as a mass or hemorrhage. Lateral tongue biting and a post-ictal phase suggest a seizure, although incontinence or tonic-clonic movements are not necessarily specific.39,41 Check medication levels of patients with known seizures if they are taking medications with available assays. Evaluate for meningeal signs and fever as a cause of seizure. Evaluate a creatinine kinase (CK) to identify the diagnosis of rhabdomyolysis secondary to unwitnessed seizure activity, prolonged immobility, or compartment syndrome. Examine all extremities thoroughly for compressive injuries, particularly in the anticoagulated patient. For CK elevated above five times the upper limit of normal, manage the patient with hydration, electrolyte evaluation and correction, and monitoring of renal function and urinary output. Consider metabolic derangements as the cause of altered mental status without focal deficits, such as hypertensive encephalopathy, uremic encephalopathy, hyperammonemia, thyroid storm or thyrotoxicosis, and myxedema coma.
Infectious
Elderly patients may not mount a fever or leukocytosis as a clue for sepsis.39 Evaluate for systemic inflammatory response syndrome (SIRS) criteria, including heart rate > 90 beats per minute, temperature < 36°C or > 38°C, respiratory rate > 20 breaths per minute, PaCO2 < 32 mmHg, white blood cell count < 4 × 109 cells/L or > 12 × 109 cells/L, and immature bands > 10%. Ask about preceding infectious symptoms, such as respiratory illness, urinary symptoms, and fever, chills, or malaise in all fall patients. Urinary tract infections and lower respiratory tract infections are the most commonly found infectious sources in fall patients.60,61 Examine the patient’s skin, since cellulitis may go unnoticed. If infection is suspected, collect blood cultures to ensure proper coverage and length of treatment for admitted patients. Lactic acidemia, a nonspecific estimate of decreased tissue perfusion, can be associated with infection and may serve as a laboratory marker of resuscitation for inpatient providers. Follow Surviving Sepsis guidelines to include hemodynamic resuscitation and early antimicrobials to cover likely pathogens.62 Use norepinephrine, then vasopressin as initial vasopressor medications to achieve a mean arterial pressure goal of > 65 mmHg, and avoid low-dose dopamine for renal protection. Updates from the 2016 Surviving Sepsis Campaign also include a red blood cell transfusion goal of hemoglobin ≥ 7.0 g/dL, except in cases of acute myocardial infarction, hemorrhage, and hypoxemia, where the transfusion threshold is higher. Central venous pressure is no longer recommended as a sole hemodynamic evaluation monitor, so use multiple dynamic monitors.62
Special Populations
There is a four-fold increase of falls in dialysis patients compared to their age-matched peers.63 Half of dialysis patients are older than 65 years of age.63 Hemodialysis patients have protein wasting leading to malnutrition, decreased bone density, chronic inflammation, cognitive decline, and reduced physical capabilities due to decreased muscle mass and fitness.63,64 Maintain a high clinical suspicion for fractures in this population, even with low mechanisms of injury. Dialysis patients also have a higher incidence of polypharmacy, compounding their increased risk.63
Chronic alcohol use in elderly patients can contribute to even greater risks of trauma from falls through increased cerebral volume loss, coagulopathies through liver disease, and an overall weaker immune system. Alcohol use has been found to be associated with an increased severity of injury in elderly outdoor falls.65 IV substance abuse increases the patient’s risk for bloodborne pathogens of hepatitis B, hepatitis C, or HIV, which complicate medical and trauma management. Substance abuse is expected to increase among the elderly population in the next decade. Elderly trauma patients should be screened for alcohol and substance use to determine the potential benefit of social work or behavioral health interventions in this currently under-evaluated population.66
Special Considerations and Controversies
Cost
Healthcare costs exceed the gross domestic product growth per capita in the United States, a trend that is expected to continue.2 Falls in older adults add to the already burdened global healthcare system.9 Efficient use of evaluation tools can assist in judicious medically appropriate management. A urinalysis is relatively inexpensive (about $5-15), but a chest X-ray costs $420 on average.67,68 CTs represent the highest cost and the area for greatest improvement. For example, abdominal solid organ injuries after a fall in the elderly are found in < 1% of patients, and even fewer warrant surgical intervention.5,14 A CT evaluation of a low-impact fall for occult intra-abdominal injuries likely has a low clinical yield for patients with a reassuringly negative physical exam as well as a negative FAST exam.5
As another example, head CT evaluations in elderly patients represent a potential for process improvement. Older adults at baseline mental status with low-risk falls without loss of consciousness or signs of head trauma may not need a head CT.69 However, this is a controversial topic. Elderly patients who present from a noninstitutional setting or who demonstrate signs of head trauma are at an increased risk for ICH, even in the absence of focal neurologic findings.50 The Canadian CT Head Rule emphasizes age ≥ 65 years or anticoagulation use as risk factors for major head injury. Conversely, the New Orleans Criteria indicate a head CT for head injury patients with risk stratification based on age > 60 years and loss of consciousness. Balance the cost of a head CT, between $211 and $2,200 depending on location,70 with the patient’s risks.
Abuse
Elderly patients are particularly vulnerable to caregiver abuse, including injury and neglect. Nonaccidental trauma and neglect should be considerations for injuries in the elderly. Head, neck, and face trauma are the most common areas of injury in elder physical abuse.71 For example, traumatic hair pulling may lead to subgaleal hematoma, which is easily mistaken for a head injury from a fall.71 Maxillofacial and extremity bruising should be evaluated for various stages of healing and the shape of hands or objects. First responders provide additional information about the patient’s living situation and details of the story that an altered or injured elder may not be able to supply.72 Complete a physical exam for other signs of neglect, such as skin ulcerations and poor hygiene. Elder neglect is the most common cause of elder abuse.73 Do not assume that malnutrition and dehydration are the results of self-neglect in a debilitated patient. Several risk factors for elder abuse include financial dependence of the caregiver upon the elder, or substance abuse by the caregiver.71 Contact adult protective services if abuse is suspected and understand the reporting laws in your state.72
Disposition
Disposition needs to be carefully considered in the older adult with a fall, driven by diagnosis and, most importantly, the patient’s goals of care. Respect patient autonomy: When the information is available, follow the patient’s living will. Be familiar with local state laws about do not resuscitate orders, living wills, and power of attorney. It is the physician’s responsibility to provide counsel and psychosocial support, and to present all treatment options to their patients. Consider safety, ability to obtain follow-up, transportation issues, caregiver limitations, and the possibility of elder abuse. Outcomes studied in both medical and surgical admissions of ground level fall blunt traumas at a single center showed no difference in survival when adjusted for comorbidities and trauma injury severity score,3 so an admission to the most appropriate service is warranted according to local practices. Admit to the ICU for hemodynamic instability, polytrauma, intracranial trauma, or comorbidities that need to be managed closely. Discharge can be considered in those without significant traumatic injury, a discovered and benign cause of falling, and access to adequate follow-up. The Eastern Association for the Surgery of Trauma guidelines recommend that patients > 65 years of age with comorbid conditions or severe anatomic injuries be transferred to trauma centers because they have a higher tendency to require specialty care.15 Geriatric patients would benefit from referral to multidisciplinary providers if possible within the community, including evaluation referrals for vision, hearing, and cognitive functioning as well as a home safety assessment. Counsel patients about fall prevention, including transfer safety and environmental safety for tripping or slipping hazards, and involve family/caregivers in the discussion if possible.9
Summary
Older adults are the fastest growing patient population in trauma.3 Falls in patients older than 65 years of age are an increasingly common presentation in U.S. EDs, and intricate knowledge and confidence in the evaluation and management of these patients is vital. Elderly patients are complex because of their physiologic differences and comorbidities in addition to higher morbidity and mortality after low-level trauma. Disposition must be considered not only for the patient, but also for their caregivers or family members.
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Falls in patients older than 65 years of age are an increasingly common presentation in U.S. emergency departments, and intricate knowledge and confidence in the evaluation and management of these patients is vital.
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