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ABSTRACT & COMMENTARY

Apolipoprotein E and CSF Levels in Men and Women With Alzheimer’s Disease

Apolipoprotein E epsilon 4 (APOE4) genotype, the stronger genetic risk factor for late-onset Alzheimer’s disease, negatively affects cerebrospinal levels of tau protein in a sex-dependent manner, whereby the effect of APOE4 is stronger in women than men.