An anniversary, especially a 10-year one, would typically be a cause for a festive celebration. However, at this year's 31st annual International Stroke Conference, sponsored by the American Stroke Association (ASA; Dallas) and held here in February, the 10th anniversary of the FDA's 1996 approval of Genentech's (South San Francisco, California) clot-busting drug tissue plasminogen activator (tPA) was noted in muted style.