Psychological Distress in the Medically Ill
Psychological Distress in the Medically Ill
Authors: Randy A. Sansone, MD, Professor, Departments of Psychiatry and Internal Medicine, Wright State University School of Medicine, Dayton, Ohio, and Director, Psychiatry Education, Kettering Medical Center, Kettering, Ohio; and Lori A. Sansone, MD, Family Practice, Alliance Physicians, Dayton, Ohio.
Editor’s Note—The term, "psychological distress," refers to a range of psychological phenomena from subclinical symptoms to major psychiatric disorders. The relationship between psychological distress and medical illness is a complex one, and their mutual intersection is unfortunately frequent. Up to 10-15% of patients with acute medical illness experience depression, as well as 25-50% of those with chronic illness.1 The presence of psychological distress may deter both effective medical intervention as well as the outcome of medical illness. In this regard, studies indicate that psychological distress among medically ill patients may increase the length of hospitalization,2 result in decreased patient compliance,3 contribute to possible secondary medical complications,3 and increase patient rehospitalization rates.4
Due to the frequency of psychological distress in the medically ill and its potential effects on medical care, recognition and treatment of symptoms among the medically ill is clinically important. In this article, we review the various contributory factors to psychological distress in medically ill patients, and we offer suggestions for assessment and treatment.
| Contributory Factors To Psychological Distress |
Factors that Precede Medical Illness
Prior to the onset of medical illness, an individual may have pre-existing psychological factors that manifest or undergo exacerbation during illness. These factors may include early life experiences around illness (including cultural influences) as well as pre-existing major psychiatric or personality disorders.
Early Life Experiences
Childhood experiences tend to shape how individuals react to situations in adulthood. With regard to medical illness, negative early life experiences may affect a patient’s reaction to and ability to cope with illness in adulthood (see Figure 1). For example, family members may have used illness to manipulate relationships—ie, members may have used illness as a vehicle to communicate emotional and/or physical needs, or to emotionally control or take advantage of the ill member. Illness may not have been acceptable in the family-of-origin, resulting in the ill individual being stigmatized and shunned. In addition, family members may have perceived illness as a consuming and unnecessary family burden, both emotionally and financially, resulting in the blaming of the victim and/or the patient when a child.
Figure.
Relationships Between Psychological
Distress and Medical Illness
 |
These ancient childhood legacies tend to re-emerge under the stress of illness and may affect the adult individual’s ability to manage dependency, trust others (ie, the ability to rely on the medical team), and resolve ambiguity (ie, teasing out treatment options, selecting medication regimens, sorting out survival rates).
Cultural influences (ie, ethnicity, religion, nationality) may also affect a patient’s experience of illness. Cultural attitudes shape one’s beliefs and feelings about aging, infirmity, and debilitation. They may affect the individual’s reactions to proposed interventions, including the right to suicide. Even the manifestations of illness are open to cultural interpretation (eg, a delirium that is culturally interpreted as a communication from long-dead ancestors).
Pre-Existing Major Psychiatric Disorders
Given their lifetime prevalence, it is expected that major psychiatric disorders will precede medical illness in some patients (see Table 1).
| Table 1. Prevalence of Several Major Psychiatric* and Personality** Disorders | |||
| Major Psychiatric Disorder |
Lifetime Prevalence (%) |
Personality Disorder |
Prevalence (%) |
|
|
|||
| Major depression | 17.1 | Paranoid | 0.5-2.5 |
| Dysthymic disorder | 6.4 | Schizoid | ? |
| Panic disorder | 3.5 | Schizotypal | 3 |
| Social phobia | 13.3 | Antisocial | 4 |
| Generalized anxiety disorder | 5.1 | Borderline | 2 |
| Alcohol dependence | 14.1 | Histrionic | 2-3 |
| Any substance abuse | 26.6 | Narcissistic | < 1 |
| Avoidant | 0.5-1.0 | ||
| Dependent | ? | ||
| Obsessive- compulsive |
1 | ||
|
|
|||
| * National Comorbidity Survey68 | |||
| ** Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)69 | |||
|
|
|||
The relationship between pre-existing psychiatric illness and current medical illness is an illusive one. In some cases, the presence of acute medical illness may cause an exacerbation of a pre-existing psychiatric condition (eg, the worsening of panic disorder symptoms with viral illness, the deepening of depression with thyroid or other hormonal diseases).
However, recent research is clarifying that psychiatric illness may function as a contributory factor to evolving medical illness. For example, in a review of 15 epidemiological studies, Roose and colleagues5 concluded that pre-existing depressive symptoms increased the risk of developing ischemic heart disease. This unexpected relationship may be mediated by several variables including hypothalamic-pituitary-adrenocortical axis hyperactivity (eg, elevated cortisol levels) as well as elevated levels of plasma catecholamines (eg, norepinephrine), resulting in platelet aggregation.5 In addition to ischemic heart disease, depressive symptoms may predispose individuals to congestive heart failure,6 risk of death from myocardial infarction,7 and cerebral vascular accidents.5 Therefore, rather than conceptualizing mood and anxiety disorders as outgrowths of medical illness, these disorders may actually contribute to medical illness in some individuals.
Personality Disorders
Some manifestations of psychological distress in medically ill patients may be due, in part, to an underlying personality disorder. With their onset in childhood, personality-disordered behaviors may be intensified by medical illness. For example, the narcissistic individual may experience a heightening of control needs, resulting in highly demanding behavior. The histrionic individual may become more dramatic and flamboyant, if not more emotionally labile. The dependent individual may funnel their dependency needs into medical disability. On the contrary, some patients with personality disorders, such as borderline personality, may temporarily stabilize during a medical crisis, followed by a postcrisis worsening of personality-disorder symptoms. The prevalence rates of these disorders in the general population are shown in Table 1.
|
Concurrent Psychiatric Factors |
New-Onset Psychiatric Disorders
After the onset of medical illness, many patients experience new-onset major psychiatric disorders. These secondary disorders are most frequently characterized by either depressive and/or anxiety symptoms. For example, depression is particularly frequent among sufferers of neurological or cardiovascular disease8 and up to 50% of patients with cancer experience depression or anxiety.9 The majority of these new-onset syndromes are manifestations of, or reactions to, illness9 or its treatment (eg, medications10). Once established, it is possible that psychiatric illness and medical illness function in a reciprocal fashion, with each reinforcing the other. As with pre-existing major psychiatric disorders, these secondary mood and anxiety disorders have the same potential to interfere with treatment by reducing compliance, optimism, and cooperation.
Psychodynamics Related to Medical Illness
A variety of psychodynamics may be associated with medical illness (see Table 2). Invariably, the onset of medical illness is accompanied by loss, whether functional (eg, use of one’s legs), economic (ie, inability to work), relational (eg, loss of significant other, exhausted social support), and/or self-esteem (ie, loss of productivity, less value to self). The complex dynamics around loss may function as contributory factors to incipient mood disorders.
| Table 2. Examples of Psychological Dynamics Related to Medical Illness | |
| • | Increased dependency on others |
| • | Greater needs for social support |
| • | Mourning of losses (eg, economic, ability to work, sense of future) |
| • | Potentially dramatic changes in daily life patterns |
| • | Needs to re-assess priorities in life with greater attention to future |
| • | Social alienation from others (eg, social stigmatization with HIV) |
| • | Threat of premature death |
| • | Need to deal with ambiguity (eg, treatment response, prognosis) |
| • | Secondary gain (eg, nurturing, controlling other, sustaining dependency) |
|
|
|
In addition to facing the challenges around loss, reaction to the disease process, itself, may be maladaptive. As examples, some cancer patients attempt to overly control their feelings in an effort to literally control the cancer. As an approach to curing cancer, patients may rigidly adhere to a positive attitude, even at the expense of dealing with by-product emotional issues.9
|
Assessment of Psychological Distress in the Medically Ill Patient |
Clinical Assessment
The primary care clinician should retain a high level of suspicion and carefully scrutinize medically ill patients for mood and anxiety disorders due to their anticipated prevalence in this population. The unique advantage of longitudinal experience with the patient and ongoing contact with the family may enable greater awareness of changes in the patient’s behavior and emotions.
While several psychological measures that assess mood and anxiety are available, the direct verbal approach may be the most efficient. Among a group of terminally ill patients, investigators found that asking the direct question, "Are you depressed?," was more valid than 3 sophisticated psychological assessments for depression.11
Psychological Measures for Depression and Anxiety
Clinically established12 psychological tools for the assessment of depression and anxiety include the Beck Depression Inventory13 and Zung Self-Rating Depression Scale.14 While potentially helpful, assessment with these measures may be complicated by symptoms that are due to medical illness and not to mood or anxiety disorders (eg, sleep disturbance, appetite, weight, or psychomotor changes),8 resulting in false positives.
Psychological Measures of the Illness Experience
Used primarily for research purposes, psychological measures for assessing the illness experience include the Millon Behavioral Health Inventory,15 the Psychological Adjustment to Illness Scale,16 and the Illness Behavior Questionnaire.17 Some scales are highly specific to the type of medical illness, such as the Mental Adjustment to Cancer Scale.18
Assessment of Suicidal Ideation
The patient’s desire to end pain, suffering, family stress, and financial exhaustion may precipitate the contemplation of suicide. The issue of suicide should be explored directly with high-risk patients (eg, those with impending grueling death; comorbid severe mood disorders; and/or histories of suicide attempts, psychiatric difficulties, and substance abuse). When patients actively disclose their contemplation of suicide, the immediate clinical issue is the risk of intent.
In assessment, it is important to differentiate suicidal thoughts from imminent behavior, as many individuals contemplate thoughts of "not going on" but readily acknowledge that they would never attempt suicide. The clinician might ask, "Have you had any thoughts of harming yourself? Do you think that you might genuinely act upon these thoughts?" If imminent risk is present, the patient requires prompt psychiatric evaluation and possible psychiatric hospitalization, whether voluntary or not, for further assessment.
| Treatment Approach |
Pre-Existing and Concurrent Major Psychiatric Disorders
Mood and anxiety disorders are statistically the most likely psychiatric disorders to be present. Their treatment is approached in a traditional fashion—with antidepressant medications as well as consideration of psychotherapy.
Antidepressant Medications
In the medically ill patient, the selective serotonin reuptake inhibitors (SSRIs) are typically favored over other types of antidepressants because of their: 1) proven ability to treat numerous psychiatric symptoms (eg, depression, anxiety, social phobia, panic attacks, impulsivity, worry and rumination, post-traumatic stress disorder, obsessive-compulsive disorder);19 and 2) mild side effects. The latter is an advantage in medically ill patients who are physically compromised and on other medications.20
The side effects of SSRIs tend to be minimal and may include headaches, nausea, sexual dysfunction, gastrointestinal symptoms, and varying potentials for P-450 drug interactions.21 SSRIs have no known cognitive effects,22 which support their use in neurological disorders. SSRIs have few cardiovascular effects,23 although one group of investigators described infrequent abnormalities (ie, first-degree atrioventricular block, QTc prolongation, orthostatic hypotension).24 Among diabetics, SSRIs tend to reduce glucose levels whereas tricyclic antidepressants have the opposite effect.25
As a class, SSRIs can cause some unexpected but infrequent side effects. For example, when combined with other serotonergic compounds (eg, buspirone), additive effects may precipitate serotonin syndrome, which is characterized by mental confusion, and autonomic and neuromuscular (eg, myoclonus, agitation, hyperreflexia) symptoms.26 On rare occasions, SSRIs have precipitated pancreatitis,27 bleeding events,28 hyponatremia,29 falls,30 weight loss in the elderly,31 and extrapyramidal side effects (most commonly akathisia32). The latter finding does not preclude their use in Parkinson’s disease.33
SSRIs may also cause discontinuation syndrome, a collection of symptoms that robustly and transiently emerge following abrupt discontinuation of the medication, usually after several months of continuous exposure. Symptoms may include, but are not limited to, nausea, headaches, gait disturbances, mood lability, irritability, and insomnia. Compared with other SSRIs, paroxetine appears to have a higher frequency of discontinuation syndrome.34 Treatment of discontinuation syndrome entails resumption of the causative SSRI and gradual tapering of the drug.
There are clinical differences among SSRIs. For example, citalopram may be safely taken by patients prescribed coumadin35 but is potentially lethal in overdose due to cardiac arrhythmias.36 Fluoxetine may cause over-activation, insomnia, and akathisia. Sertraline may cause loose stools. Paroxetine has some anticholinergic activity and may cause dry mouth and constipation.37 Finally, fluvoxamine has extensive potential drug interactions.38
Other antidepressant types may also be considered in medically ill patients and most, if not all, have both antidepressant and anxiolytic effects.39 Amitriptyline, a tricyclic antidepressant (TCA), may be effective in pain management40 as well as insomnia. However, TCAs have anticholinergic effects that may exacerbate confusional states and cause cardiovascular symptoms (eg, tachycardia, lightheadedness). TCAs are also extremely dangerous in overdose because of their effects on cardiac conduction.41
Venlafaxine has diverse neurotransmitter effects,42 making it an option for nonresponders to SSRIs. Like SSRIs, venlafaxine is effective for the treatment of both depression and anxiety.43 Potential limitations of venlafaxine include diastolic blood pressure elevation and discontinuation syndrome with abrupt cessation.44
Trazodone may be prescribed as a long-term, nonaddicting hypnotic. With few drug interactions, side effects include light-headedness, nausea, and the very rare occurrence of priapism (prolonged, painful erection which may require medical management).45 Another hypnotic option is mirtazapine, which may precipitate weight gain as well as somnolence, making it a practical choice for the low-weight insomniac.
Several antidepressants pose specific risks. For example, bupropion may lower the seizure threshold, is contraindicated in patients with a history of seizures or eating disorders, and should be used with caution in patients with neurological compromise or head injury. Nefazodone undergoes a relatively complex metabolism in the liver (ie, to be avoided in those with liver disease) and, in a small number of patients, has precipitated fulminant hepatic failure requiring liver transplantation.46
Augmentation Strategies
An augmentation strategy entails the addition of a second psychotropic drug to the first, for patients with partial treatment responses. This approach may be specifically useful for partial responders who are unable to tolerate higher doses of the primary antidepressant.
Practical augmentors in the primary care setting include buspirone47 or gabapentin,48 at dosages that are usually lower than typically prescribed. Buspirone may be started at 5 mg per day and gradually increased to 10 mg twice per day. Side effects may include headaches, nausea, and/or sedation. Buspirone, in combination with an SSRI, has on occasion precipitated serotonin syndrome.
Gabapentin may be started at 100 mg at bedtime and gradually increased to 600 mg per day in divided doses (ie, twice daily). Side effects may include light-headedness and sedation. Gabapentin has few drug interactions due to renal excretion and is safe in overdose but is potentially teratogenic.
Augmentation trials with either drug should be 14-21 days in duration. Dosages of the augmenting drug should be increased gradually, as tolerated. If the patient does not respond to either strategy, consultation with a psychiatrist is warranted. The psychiatrist may attempt other augmentation strategies including the addition of low-dose atypical antipsychotics (eg, risperidone, olanzapine)49 or methylphenidate (primarily used on a temporary basis in the elderly to initiate a clinical response).50
Supportive Psychotherapy Intervention in the Primary Care Setting
At the outset, education on the natural course and treatment of the psychiatric and/or medical illness is essential, if such information is available. Supportive psychotherapy may be helpful for sorting out acute psychosocial and relationship stressors. Acute problem-solving may be indicated for resolving practical life issues such as inexpensive resources for medical supplies, financial aid, child-care needs, transportation difficulties, concerns about sexual functioning, and cosmetic concerns (eg, hair loss with chemotherapy). One invaluable role of the primary care clinician is the triaging of specific problems to appropriate adjunctive health care personnel (eg, social worker, psychiatric referral) and community resources (eg, wig salons).
Referral for Mental Health Intervention
When the patient’s mental health needs exceed treatment resources in the primary care setting, the clinician should consider a referral for psychological intervention. Referral may precipitate various patient concerns including social stigmatization, confusion about the relationship between emotions and medical illness, and misinterpretation of the referral to a mental health professional as abandonment by the physician.51 We advise being alert to these issues and explicitly exploring the patient’s reaction to the referral ("How do you feel about my referring you to a mental health professional?")
An important consideration is the timing of the psychotherapy referral. Coping strategies are ideally taught to the patient and family when motivation and physical stamina are relatively high (ie, the early phases of illness).52 Referral during the late phases of illness may preempt some types of interventions.
Mental Health Treatment Options
Various psychotherapy approaches are potentially effective in medically ill patients,53-62 which underscores the importance of individualizing treatment. Therapy options include: 1) acute problem-solving in a brief treatment model;63 2) cognitive-behavioral techniques, which systematically elicit cognitive distortions, modify them, and improve emotional responses;64,65 3) psychodynamic psychotherapy, which explores the effect of early life experiences on current behavior and relationships;66 4) family intervention to obtain background information, provide education, liaison between the patient and/or hospital personnel, and explore needs for professional support (eg, the spouse who is depressed and needs antidepressant medication); and 5) group therapy.
Each of the first 4 treatment components may be undertaken through group intervention. Potential advantages of group treatment include emphasizing the universality of experiences, dealing with medical disability on a broader level, emotional sharing, sorting out relationships, and acknowledging and attempting to resolve grief and loss. Patients also have the opportunity to build social bonds, use the group experience as a working lab to practice and express emotions, process feelings about death and dying, and redefine life goals.9
Group referral may be complicated by the patient’s individual needs (eg, social comfortability with groups, level of debilitation, type of medical illness), the availability of such groups or sufficient fellow patients who meet criteria for entry (eg, HIV infection), confidentiality concerns, and the fact that members may have to be prepared for the inevitable death of some participants. Groups may be time-limited or ongoing,61 open or closed to new members, and/or designed specifically for family members.67
Personality Disorder
The preceding treatment options effectively address many of the substrates for psychological distress among the medically ill. However, the presence of personality disorder may be a challenging treatment issue. Because of their longstanding nature, personality disorders tend to be tenacious and difficult to change. Most theorists believe that long-term treatment is required and the prognosis is oftentimes guarded (eg, schizoid personality disorder). Few studies confirm the efficacy of treatment for personality disorders, and some disorders, such as antisocial personality disorder, have questionable responses to treatment.
While the intersection of medical illness and personality disorder can be exasperating for the clinician as well as the family and health care team, it is important to emphasize that it is not always a meaningful issue in treatment. For example, in cancer victims with poor prognoses, personality disorder treatment is neither realistic nor appropriate. Intervention may function to contain the patient’s behavior to enable the health care team and/or family to function more effectively.
Conclusions
Medical illness is frequently accompanied by psychological distress. Psychological distress may result from an exacerbation of pre-existing psychological factors and/or concurrent or secondary factors. Following assessment, management in the primary care setting may include psychotropic medication, supportive intervention, and/or referral for mental health intervention. Treatment may not only improve the patient’s overall sense of well being, but health care use, as well.
References
1. Nesse RE, Finlayson RE. Management of depression in patients with coexisting medical illness. Am Fam Physician. 1996; 53:2125-2133.
2. Verbosky LA, Franco KN, Zrull JP. The relationship between depression and length of stay in the general hospital patient. J Clin Psychiatry. 1993;54:177-181.
3. Lustman PJ, Clouse RE, Freedland KE. Management of major depression in adults with diabetes: Implications of recent clinical trials. Semin Clin Neuropsychiatry. 1998;3:102-114.
4. Black JL, et al. Effect of intervention for psychological distress on rehospitalization rates in cardiac rehabilitation patients. Psychosomatics. 1998;39:134-143.
5. Roose SP, Glassman AH, Seidman SN. Relationship between depression and other medical illnesses. JAMA. 2001;286: 1687-1690.
6. Abramson J, et al. Depression and risk of heart failure among older persons with isolated systolic hypertension. Arch Intern Med. 2001;161:1725-1730.
7. Severus WE, Littman AB, Stoll AL. Omega-3 fatty acids, homocysteine, and the increased risk of cardiovascular mortality in depressive disorder. Harv Rev Psychiatry. 2001;9:280-293.
8. Sutor B, et al. Major depression in medically ill patients. Mayo Clin Proc. 1998;73:329-337.
9. Spiegel D, Classen C. Group Therapy for Cancer Patients: A Research-Based Handbook of Psychosocial Care. New York, NY: Basic Books; 2000.
10. Valente SM, Saunders JM, Cohen MZ. Evaluating depression among patients with cancer. Cancer Pract. 1994;2:65-71.
11. Chochinov HM, Wilson KG, Enns M, Lander S. "Are you depressed?" Screening for depression in the terminally ill. Am J Psychiatry. 1997;154:674-676.
12. Sansone RA, Wiederman MW, Sansone LA. Use of psychological measures in primary care. Arch Fam Med. 1998;7:367-369.
13. Beck AT, et al. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561-571.
14. Zung WWK. A self-rating depression scale. Arch Gen Psychiatry. 1965;12:63-70.
15. Sweet JJ, et al. The Millon Behavioral Health Inventory: concurrent and predictive validity in a pain treatment center. J Behav Med. 1985;8:215-226.
16. Schindler BA, Shook J, Schwartz GM. Beneficial effects of psychiatric intervention on recovery after coronary artery bypass graft surgery. Gen Hosp Psychiatry. 1989;11:358-364.
17. Pilowsky I, Spence ND. Illness Behavior Questionnaire, Second Edition. South Australia: University of Adelaide; 1983.
18. Greer S, Moorey S, Watson M. Patients’ adjustment to cancer: The Mental Adjustment to Cancer (MAC) scale vs clinical ratings. J Psychosom Res. 1989;33:373-377.
19. Schatzberg AF. New indications for antidepressants. J Clin Psychiatry. 2000;61:9-17.
20. Kurzthaler I, et al. Risk profile of SSRIs in elderly depressed patients with comorbid physical illness. Pharmacopsychiatry. 2001;34:114-118.
21. Cupp MJ, Tracy TS. Cytochrome P450: New nomenclature and clinical implications. Am Fam Physician. 1998;57:107-116.
22. Gray SL, Lai KV, Larson EB. Drug-induced cognition disorders in the elderly: incidence, prevention and management. Drug Saf. 1999;21:101-122.
23. Glassman AH, Rodriguez AI, Shapiro PA. The use of antidepressant drugs in patients with heart disease. J Clin Psychiatry. 1998;59:(suppl 10):16-21.
24. Rodriguez de la Torre B, et al. Serum levels and cardiovascular effects of tricyclic antidepressants and selective serotonin reuptake inhibitors in depressed patients. Ther Drug Monit. 2001;23:435-440.
25. Goodnick PJ. Use of antidepressants in treatment of comorbid diabetes mellitus and depression as well as in diabetic neuropathy. Ann Clin Psychiatry. 2001;13:31-41.
26. Lane R, Baldwin D. Selective serotonin reuptake inhibitor-induced serotonin syndrome: Review. J Clin Psychopharmacol. 1997;17:208-221.
27. Kvande KT, Madsen S. Selective serotonin uptake inhibitors and pancreatitis. Tidsskr Nor Laegeforen. 2001;121:177-178.
28. Layton D, et al. Is there an association between selective serotonin reuptake inhibitors and risk of abnormal bleeding? Results from a cohort study based on prescription event monitoring in England. Eur J Clin Pharmacol. 2001;57:167-176.
29. Kirby D, Ames D. Hyponatraemia and selective serotonin re-uptake inhibitors in elderly patients. Int J Geriatr Psychiatry. 2001;16:484-493.
30. Arfken CL, Wilson JG, Aronson SM. Retrospective review of selective serotonin reuptake inhibitors and falling in older nursing home residents. Int Psychogeriatr. 2001;13:85-91.
31. Herrmann N. Use of SSRIs in the elderly: Obvious benefits but unappreciated risks. Can J Clin Pharmacol. 2000;7:91-95.
32. Gerber PE, Lynd LD. Selective serotonin-reuptake inhibitor-induced movement disorders. Ann Pharmacother. 1998;32: 692-698.
33. Lane RM. SSRI-induced extrapyramidal side effects and akathisia: Implications for treatment. J Psychopharmacol. 1998;12:192-214.
34. Coupland NJ, Bell CJ, Potokar JP. Serotonin reuptake inhibitor withdrawal. J Clin Psychopharmacol. 1996;16:356-362.
35. Priskorn M, et al. Investigation of multiple dose citalopram on the pharmacokinetics and pharmacodynamics of racemic warfarin. Br J Clin Pharmacol. 1997;44:199-202.
36. Power A. Drug treatment of depression. Citalopram in overdose may result in serious morbidity and death. BMJ. 1998;316: 307-308.
37. Richelson E. Pharmacology of antidepressants—characteristics of the ideal drug. Mayo Clin Proc. 1994;69:1069-1081.
38. Riesenman C. Antidepressant drug interactions and the cytochrome P450 system: A critical appraisal. Pharmacother. 1995;15:84S-99S.
39. Nutt D. Treatment of depression and concomitant anxiety. Eur Neuropsychopharmacol. 2000;4:S433-437.
40. Bryson HM, Wilde MI. Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states. Drugs Aging. 1996;8:459-476.
41. Sasyniuk BI, Jhamandas V, Valois M. Experimental amitriptyline intoxication: Treatment of cardiac toxicity with sodium bicarbonate. Ann Emerg Med. 1986;15:1052-1059.
42. Bourin M. Psychopharmacological profile of venlafaxine. Encephale. 1999;25:21-25.
43. Sheehan DV. Attaining remission in generalized anxiety disorder: venlafaxine extended release comparative data. J Clin Psychiatry. 2001;62(suppl 19):26-31.
44. Fava M, et al. Emergence of adverse events following discontinuation of treatment with extended-release venlafaxine. Am J Psychiatry. 1997;154:1760-1762.
45. Carson CC, Mino RD. Priapism associated with trazodone therapy. J Urol. 1988;139:369-370.
46. Aranda-Michel J, et al. Nefazodone-induced liver failure: Report of three cases. Ann Intern Med. 1999;130:285-288.
47. Dimitriou EC, Dimitriou CE. Buspirone augmentation of antidepressant therapy. J Clin Psychopharmacol. 1998;18:465-469.
48. Ghaemi SN, et al. Gabapentin treatment of mood disorders: A preliminary study. J Clin Psychiatry. 1998;59:426-429.
49. Shelton RC, et al. A novel augmentation strategy for treating resistant major depression. Am J Psychiatry. 2001;158:131-134.
50. Challman TD, Lipsky JJ. Methylphenidate: Its pharmacology and uses. Mayo Clin Proc. 2000;75:711-721.
51. Bursztajn H, Barsky AJ. Facilitating patient acceptance of a psychiatric referral. Arch Intern Med. 1985;145:73-75.
52. Localzo M. Psychological approaches to the management of pain in patients with advanced cancer. Hematol Oncol Clin North Am. 1996;10:139-155.
53. Conte HR. Review of research in supportive psychotherapy: An update. Am J Psychother. 1994;48:494-504.
54. Rybarczyk B, et al. Comparing mind-body wellness interventions for older adults with chronic illness: Classroom versus home instruction. Behav Med. 1999;24:181-190.
55. Ehlers A, Stangier U, Gieler U. Treatment of atopic dermatitis: a comparison of psychological and dermatological approaches to relapse prevention. J Consult Clin Psychol.1995;63:624-635.
56. Sullivan MJ, Hawthorne MH. Nonpharmacologic interventions in the treatment of heart failure. J Cardiovasc Nurs. 1996;10: 47-57.
57. Schindler BA, Shook J, Schwartz GM. Beneficial effects of psychiatric intervention on recovery after coronary artery bypass graft surgery. Gen Hosp Psychiatry. 1989;11:358-364.
58. Kibby MY, Tye VL, Mulhern RK. Effectiveness of psychological intervention for children and adolescents with chronic medical illness: a meta-analysis. Clin Psychol Rev. 1998;18:103-117.
59. Cuijpers P. Prevention of depression in chronic general medical disorders: A pilot study. Psychol Rep. 1998;82:735-738.
60. Heymann-Monnikes I, et al. The combination of medical treatment plus multicomponent behavioral therapy is superior to medical treatment alone in the therapy of irritable bowel syndrome. Am J Gastroenterol. 2000;95:981-994.
61. Compton AB, Purviance M. Emotional distress in chronic medical illness: treatment with time-limited group psychotherapy. Mil Med. 1992;157:533-535.
62. Forrester B, et al. Group psychotherapy during radiotherapy: Effects on emotional and physical distress. Am J Psychiatry. 1993;150:1700-1706.
63. Levenson H, Hales RE. Brief psychodynamically informed therapy for medically ill patients. In: Stoudemire A, Fogel BS, eds. Medical-Psychiatric Practice, Vol. 2. Washington, DC: American Psychiatric Press; 1993:3-37.
64. Broderick JE. Mind-body medicine in rheumatologic disease. Rheum Dis Clin North Am. 2000;26:161-176.
65. Antoni MH, et al. Cognitive-behavioral stress management intervention buffers distress responses and immunologic changes following notification of HIV-1 seropositivity. J Consult Clin Psychol. 1991;59:906-915.
66. Eisendrath SJ. Brief psychotherapy in medical practice. Key to success. West J Med. 1993;158:376-378.
67. Gonzalez S, Steinglass P, Reiss D. Putting the illness in its place: discussion groups for families with chronic medical illnesses. Fam Process. 1989;28:69-87.
68. Kessler RC, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric diagnoses in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry. 1994;51: 8-19.
69. Author. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.
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